Cornea and Anterior Segment Service, L V Prasad Eye Institute, Bhubaneswar, Odisha, India.
Indian J Ophthalmol. 2023 Feb;71(2):505-509. doi: 10.4103/ijo.IJO_1288_22.
This study was performed to determine the demographic profile and clinical characteristics in patients with Fuchs' endothelial corneal dystrophy (FECD) reporting to a tertiary eye care center in India. It is a retrospective, single-center, observational study.
The study included 280 patients (559 eyes) diagnosed with FECD presenting between January 2013 and December 2020. The data was collected from the electronic medical record system of the institute. Patient data included demographic features, clinical characteristics, investigations, and surgical interventions.
The mean age of the patients was 62 years. Late-onset FECD (95.7%) was more common than early-onset FECD (4.3%). Male: female ratio for late-onset FECD and early-onset FECD was 1:1.65 and 3:1, respectively. More than one-third of the patients had associated systemic history. Preexisting ocular diseases were seen in 5.9% of eyes. Blurring of vision was seen in 383 eyes (68.5%), 13 eyes (2.1%) had glare, and 163 eyes (29.2%) were asymptomatic. A total of 113 surgical interventions were done in 108 eyes (including repeat transplants). Only cataract surgery was done in 40 (7.2%) eyes, whereas penetrating keratoplasty, Descemet stripping endothelial keratoplasty, and Descemet membrane endothelial keratoplasty without or with cataract surgery (sequential or triple procedure) were done in 12 (2.1%), 47 (8.4%), and 14 (2.5%) eyes, respectively.
Patients with FECD present mostly during the sixth decade. Posterior lamellar keratoplasty is the most common transplant procedure being performed on FECD patients.
本研究旨在确定在印度一家三级眼科中心就诊的 Fuchs 内皮角膜营养不良（FECD）患者的人口统计学特征和临床特征。这是一项回顾性、单中心、观察性研究。
该研究纳入了 2013 年 1 月至 2020 年 12 月期间被诊断为 FECD 的 280 名患者（559 只眼）。数据来自该机构的电子病历系统。患者数据包括人口统计学特征、临床特征、检查和手术干预。
患者的平均年龄为 62 岁。迟发性 FECD（95.7%）比早发性 FECD（4.3%）更为常见。迟发性 FECD 和早发性 FECD 的男女比例分别为 1:1.65 和 3:1。超过三分之一的患者有相关的系统性病史。5.9%的患眼存在先前存在的眼部疾病。383 只眼（68.5%）出现视力模糊，13 只眼（2.1%）出现眩光，163 只眼（29.2%）无症状。在 108 只眼中共进行了 113 次手术干预（包括重复移植）。仅行白内障手术的眼有 40 只（7.2%），而行穿透性角膜移植术、Descemet 撕囊内皮角膜移植术和不伴或伴白内障手术的 Descemet 膜内皮角膜移植术（序贯或三联手术）的眼分别有 12 只（2.1%）、47 只（8.4%）和 14 只（2.5%）。
FECD 患者主要在第六个十年就诊。后板层角膜移植术是最常进行的 FECD 患者移植手术。
