Department of Neuro Ophthalmology, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
Indian J Ophthalmol. 2023 Feb;71(2):637-642. doi: 10.4103/ijo.IJO_1407_22.
Optic neuritis, defined as inflammation of the optic nerve, is the most common optic neuropathy affecting adults. Various studies in Southeast Asia have shown that the clinical profile of optic neuritis might differ in these regions from that reported in the western literature. Through this study, we evaluate the clinical profile of pediatric optic neuritis (PON) in the Indian population.
This was a hospital-based prospective observational study. Patients with optic neuritis younger than 16 years who attended the neuro-ophthalmology clinic from May 2016 to April 2017 were included in the study.
This study included 54 eyes of 38 patients. The mean age of presentation was 10.6 years. Unilateral disease (58%) was found to be more common, and a slight female preponderance (58%) was noted. The most common feature was visual loss (96.3%). Pupillary light reflex abnormality was seen in most patients. Fundus examination revealed disk edema (77.7%) to be the most common feature. Neuroimaging was performed in 34 patients, and multiple sclerosis was diagnosed in four patients. At 3 months follow-up after treatment, 89% of eyes had best correct visual acuity of 6/9 or better (P < 0.001).
In our study, we found the clinical profile of PON to be similar to that seen in western studies as well as those done previously in the Indian population, although with a few differences.
视神经炎是一种视神经炎症，是影响成年人最常见的视神经病变。东南亚的多项研究表明，视神经炎的临床特征在这些地区与西方文献报道的可能不同。通过本研究，我们评估了印度人群中儿童视神经炎（PON）的临床特征。
这是一项基于医院的前瞻性观察性研究。2016 年 5 月至 2017 年 4 月，在神经眼科诊所就诊的年龄小于 16 岁的视神经炎患者纳入本研究。
本研究纳入了 38 名患者的 54 只眼。发病时的平均年龄为 10.6 岁。单侧疾病（58%）更为常见，且女性略占优势（58%）。最常见的特征是视力丧失（96.3%）。大多数患者存在瞳孔光反射异常。眼底检查显示盘水肿（77.7%）是最常见的特征。对 34 名患者进行了神经影像学检查，诊断出 4 名多发性硬化症患者。治疗后 3 个月随访时，89%的眼最佳矫正视力达到 6/9 或更好（P<0.001）。
在我们的研究中，我们发现 PON 的临床特征与西方研究以及印度人群以前的研究相似，尽管存在一些差异。
