Applied Physiology Laboratory and Osness Human Performance Laboratories, University of Kansas, Lawrence, Kansas.
Department of Health, Physics and Applied Sciences, Rockhurst University, Kansas City, Missouri.
J Strength Cond Res. 2023 May 1;37(5):1034-1041. doi: 10.1519/JSC.0000000000004363. Epub 2023 Jan 18.
Pearson, JR, Moodie, N, Stout, KW, Hawkins, WC, Matuszek, M, Graham, ZA, Siedlik, JA, Vardiman, JP, and Gallagher, PM. Similar responses in the Akt/protein kinase B (PKB) signaling pathway after different lower-body exercise volumes in recreationally active men. J Strength Cond Res 37(5): 1034-1041, 2023-This project examined the differences between a single set (SS) compared to multiple sets (MS) of resistance exercise on the Akt/protein kinase B (PKB) signaling pathway, the expression of insulin-like growth factor-1 ( IGF-1 ), and the receptor for IGF -1 ( IGF-1R ) to better understand the types of resistance training protocols that are most beneficial in stimulating the muscle hypertrophic response. Sixteen healthy men were randomly selected into 2 groups of 8. Subjects in each group received 3 biopsies: (a) before exercise, (b) 15 minutes postexercise, and (c) 180 minutes postexercise. Subjects in the SS group performed 1 set of leg press to failure at 80% of their predetermined 1 repetition maximum (1RM). Subjects in the MS group performed 2 sets of 10 repetitions and 1 set to failure at 80% of their predetermined 1RM, with 3 minutes of rest between each set. Our results indicated no group × time interactions in the concentration of Akt signaling proteins. Furthermore, there were no group × time interactions in IGF-1 or IGF-1R expression. However, phosphorylated 4E-binding protein 1 levels increased 150% from pre to 180 minutes post ( p = 0.005). In addition, there was a significantly greater increase in IGF-1R expression in the SS group compared with the MS group (7.99 ± 10.07 vs. 4.41 ± 6.28; p = 0.026). Collectively, we found that a SS of resistance training evokes a similar acute Akt/PKB pathway response as MS in recreationally active men.
皮尔逊，JR，莫迪，N，斯特劳特，KW，霍金斯，WC，马图泽克，M，格雷厄姆，ZA，西德利克，JA，瓦尔迪曼，JP 和加拉格尔，PM。在业余活跃男性中，不同的下肢运动容量后，Akt/蛋白激酶 B（PKB）信号通路的反应相似。J 强力量研究 37（5）：1034-1041，2023-本项目研究了单次（SS）与多次（MS）抗阻运动对 Akt/蛋白激酶 B（PKB）信号通路、胰岛素样生长因子-1（IGF-1）表达和 IGF-1 受体（IGF-1R）的差异，以更好地了解最有益于刺激肌肉肥大反应的抗阻训练方案类型。随机选择了 16 名健康男性，分为 2 组，每组 8 人。每组受试者接受 3 次活检：（a）运动前，（b）运动后 15 分钟，（c）运动后 180 分钟。SS 组的受试者在 80%的预定 1 次最大重复（1RM）下进行 1 次腿推至力竭。MS 组的受试者以 80%的预定 1RM 完成 2 组 10 次重复和 1 组力竭，每组之间休息 3 分钟。我们的结果表明，在 Akt 信号蛋白的浓度方面，没有组间×时间的相互作用。此外，IGF-1 或 IGF-1R 表达也没有组间×时间的相互作用。然而，磷酸化 4E 结合蛋白 1 水平从运动前到运动后 180 分钟增加了 150%（p=0.005）。此外，SS 组的 IGF-1R 表达明显高于 MS 组（7.99±10.07 比 4.41±6.28；p=0.026）。总的来说，我们发现单次抗阻训练会引起业余活跃男性类似的急性 Akt/PKB 通路反应。
