Department of Neurosurgery, Peking University People's Hospital, Beijing, China.
Departments of Neurology and Radiology, Peking University People's Hospital, Beijing, China.
Neurosurgery. 2023 May 1;92(5):1073-1079. doi: 10.1227/neu.0000000000002335. Epub 2023 Jan 9.
Bilateral pallidal deep brain stimulation (DBS) has been broadly accepted as a feasible surgical procedure for treating various forms of dystonia, but its effects on motor function, neuropsychological status, and mood in patients with Meige syndrome have rarely been examined.
To evaluate the effects of bilateral globus pallidus internus DBS (GPi-DBS) on the motor performance, quality of life, neuropsychological status, and mood of patients with primary Meige syndrome.
Between January 2015 and April 2019, the database of 35 patients with Meige syndrome who underwent bilateral GPi-DBS in our institution was retrospectively reviewed. The severity of dystonia, health-related quality of life, cognitive function, and mood were assessed using standardized and validated rating scales at baseline. Repeat assessment of the same domains was performed at 1 year and 3 years after neurostimulation in a similar manner.
One year and 3 years after bilateral GPi-DBS, Burke-Fahn-Marsden Dystonia Rating Scale movement scores were improved by 65% and 72% and Burke-Fahn-Marsden Dystonia Rating Scale disability scores were improved by 49% and 57%, respectively. The significant improvement in health-related quality of life observed at 1 year was sustained at 3 years. Relative to baseline and to the 1-year assessment, cognitive functions and mood remained stable after 3 years of neurostimulation. No deaths or life-threatening events were reported over the study period.
Bilateral GPi-DBS is a safe and effective approach for medically refractory Meige syndrome that can improve motor function and quality of life without cognitive and mood side effects.
双侧苍白球深部脑刺激（DBS）已被广泛接受为治疗各种形式的肌张力障碍的可行手术，但它对Meige 综合征患者的运动功能、神经心理学状态和情绪的影响很少被研究。
评估双侧苍白球 internus DBS（GPi-DBS）对原发性 Meige 综合征患者的运动表现、生活质量、神经心理学状态和情绪的影响。
回顾性分析了 2015 年 1 月至 2019 年 4 月期间在我院接受双侧 GPi-DBS 的 35 例 Meige 综合征患者的数据库。使用标准化和验证的评定量表，在基线时评估肌张力障碍的严重程度、健康相关生活质量、认知功能和情绪。以类似的方式，在神经刺激后 1 年和 3 年重复评估同一领域。
双侧 GPi-DBS 后 1 年和 3 年，Burke-Fahn-Marsden 肌张力障碍评定量表运动评分分别改善了 65%和 72%，Burke-Fahn-Marsden 肌张力障碍评定量表残疾评分分别改善了 49%和 57%。在 1 年时观察到的健康相关生活质量的显著改善在 3 年时仍然存在。与基线和 1 年评估相比，3 年后认知功能和情绪保持稳定。在研究期间没有死亡或危及生命的事件报告。
双侧 GPi-DBS 是一种安全有效的治疗药物难治性 Meige 综合征的方法，可改善运动功能和生活质量，而无认知和情绪副作用。
