Okun Sarah, Peek Allyson, Igdoura Suleiman A
Department of Biology , McMaster University, Hamilton, ON L8S 4K1, Canada.
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4K1, Canada.
Glycobiology. 2023 Apr 19;33(3):182-187. doi: 10.1093/glycob/cwad008.
Sialidases are found in viruses, bacteria, fungi, avians, and mammals. Mammalian sialidases differ in their specificity, optimum pH, subcellular localization, and tissue expression. To date, four genes encoding mammalian sialidases (NEU1-4) have been cloned. This review examines the functional impact of NEU4 sialidase on complex physiological and cellular processes. The intracellular localization and trafficking of NEU4 and its potential target molecules are discussed along with its impact on cancer, lysosomal storage disease, and cellular differentiation. Modulation of NEU4 expression may be essential not only for the breakdown of sialylated glycoconjugates, but also in the activation or inactivation of functionally important cellular events.
唾液酸酶存在于病毒、细菌、真菌、鸟类和哺乳动物中。哺乳动物的唾液酸酶在特异性、最适pH值、亚细胞定位和组织表达方面存在差异。迄今为止，已克隆出四个编码哺乳动物唾液酸酶的基因（NEU1 - 4）。本综述探讨了NEU4唾液酸酶对复杂生理和细胞过程的功能影响。讨论了NEU4的细胞内定位和运输及其潜在的靶分子，以及它对癌症、溶酶体贮积病和细胞分化的影响。调节NEU4的表达可能不仅对唾液酸化糖缀合物的分解至关重要，而且在功能重要的细胞事件的激活或失活中也必不可少。
