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游离腓骨移植分期重建感染性肱骨骨不连。

Free Vascularized Fibula Graft for Staged Reconstruction of Infected Humerus Nonunions.

机构信息

Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA; and.

Department of Orthopaedic Surgery, Cedars Sinai Hospital, Los Angeles, CA.

出版信息

J Orthop Trauma. 2023 May 1;37(5):e206-e212. doi: 10.1097/BOT.0000000000002554.

Abstract

OBJECTIVE

To evaluate the union rate and rate of postoperative complications in patients with septic nonunions of the humerus after a two-stage reconstruction using a free vascularized fibula graft.

DESIGN

Retrospective case series.

SETTING

Academic, tertiary referral center.

PATIENTS/PARTICIPANTS: Adult patients with staged reconstruction for infected nonunion of the humerus with at least 2 years follow-up after vascularized fibula graft transfer.

INTERVENTION

First, infected nonunion debridement with antibiotic spacer and external fixator placement. After antimicrobial treatment, free vascularized fibula transfer with internal fixation.

MAIN OUTCOME MEASUREMENTS

Time to union, pain, affected extremity range of motion, and function.

RESULTS

10 patients with septic humerus nonunion treated with staged reconstruction using a free vascularized fibula graft, with a mean follow-up of 32.3 months were included. After the two-stage reconstruction using a free fibula, radiographic union was achieved in 6/10 patients, with a mean time to union of 19.9 weeks. The remaining 4 patients required an additional procedure with graft augmentation and/or implant revision. After the revision procedure, union was noted in 3/4 patients, 21 weeks postoperatively. Mean patient visual analog scale pain scores improved from 5.8 preoperatively to 0.9 at final follow-up ( P = 0.02). Postoperatively, mean elbow flexion was 110 ± 20 degrees and extension 15 ± 7.5 degrees.

CONCLUSION

A two-stage reconstruction using a free fibula graft can be used in patients with septic nonunions of the humerus in the setting of multiple failed prior surgeries and compromised local biology. Additional procedures may be needed in some to achieve final union.

LEVEL OF EVIDENCE

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

摘要

目的

评估使用游离腓骨移植进行两阶段重建治疗肱骨干感染性骨不连的患者的愈合率和术后并发症发生率。

设计

回顾性病例系列研究。

地点

学术性三级转诊中心。

患者/参与者:接受分期重建治疗的感染性肱骨干骨不连的成年患者,在游离腓骨移植后至少有 2 年的随访。

干预措施

首先进行感染性骨不连清创术,并用抗生素 spacer 和外固定器固定。在抗菌治疗后,进行游离腓骨移植并内固定。

主要观察指标

愈合时间、疼痛、受累肢体活动度和功能。

结果

纳入 10 例接受游离腓骨移植分期重建治疗的感染性肱骨干骨不连患者,平均随访 32.3 个月。在游离腓骨两阶段重建后,6/10 例患者的影像学上实现了愈合,平均愈合时间为 19.9 周。其余 4 例患者需要进行额外的手术,包括移植物增强和/或植入物翻修。在翻修手术后,4 例患者中有 3 例在术后 21 周实现了愈合。患者视觉模拟评分疼痛从术前的 5.8 分改善至最终随访时的 0.9 分(P=0.02)。术后,平均肘关节屈曲为 110±20 度,伸展为 15±7.5 度。

结论

游离腓骨移植的两阶段重建可用于治疗多次手术失败和局部生物学受损的感染性肱骨干骨不连患者。在某些情况下,可能需要进行额外的手术以实现最终愈合。

证据水平

治疗性 IV 级。请参阅作者说明以获取完整的证据水平描述。

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