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伴有术中培养阳性的感染性肱骨干骨不连及疑似无菌性骨不连的治疗:一项回顾性单中心研究

Treatment of infected humeral shaft nonunion and presumed aseptic nonunion with positive intraoperative cultures: a retrospective single-center study.

作者信息

Vanpoulle Gaetan, Jalaguier Thomas, Druel Thibault, Walch Arnaud, Gazarian Aram, Mathieu Laurent

机构信息

Department of Hand and Upper Extremity Surgery, Edouard Herriot Hospital, 5 Place d'Arsonval, Lyon, 69003, France.

Department of Orthopedic, Trauma and Reconstructive Surgery, Percy Military Hospital, 101 Avenue Henri Barbusse, Clamart, 92140, France.

出版信息

Eur J Trauma Emerg Surg. 2024 Dec;50(6):2947-2954. doi: 10.1007/s00068-024-02617-5. Epub 2024 Aug 21.

Abstract

PURPOSE

The management of infected humeral shaft nonunion (HSN) remains challenging due to the lack of consensus and the potential for occult infection. The aim of this study was to evaluate a surgical strategy based on a two-stage treatment for suspected infection or a one-stage treatment for infection diagnosed retrospectively based on systematic bacteriological sampling.

METHODS

We retrospectively reviewed 16 patients with a median age of 36 years who were treated for septic HSN: 9 patients underwent a two-stage procedure using the induced membrane technique, and 7 patients were treated in a single stage. Revision parameters included achieving bone union, its time frame, and a functional assessment based on joint motion and the Quick-DASH score.

RESULTS

At a median follow-up of 47.5 months, 12 out of 16 patients were cured with acquired bone union and no septic recurrence. The median time to bone union was 5.5 months. Smoking and previous surgeries were adverse factors for bone healing. Radiological and functional outcomes were comparable between patients treated in a single stage and those treated in two stages.

CONCLUSIONS

This study confirms the relevance of one-stage surgery for HSN with occult infection and the value of systematic bacteriological sampling during the revision of humeral diaphyseal osteosynthesis.

摘要

目的

由于缺乏共识以及存在隐匿性感染的可能性,感染性肱骨干骨不连(HSN)的治疗仍然具有挑战性。本研究的目的是评估一种手术策略,即对于疑似感染采用两阶段治疗,对于根据系统细菌学采样回顾性诊断为感染的情况采用一阶段治疗。

方法

我们回顾性分析了16例平均年龄为36岁的感染性HSN患者:9例患者采用诱导膜技术进行了两阶段手术,7例患者接受了单阶段治疗。翻修参数包括实现骨愈合、其时间框架以及基于关节活动度和Quick-DASH评分的功能评估。

结果

在中位随访47.5个月时,16例患者中有12例获得了骨愈合且无感染复发而治愈。骨愈合的中位时间为5.5个月。吸烟和既往手术是骨愈合的不利因素。单阶段治疗和两阶段治疗的患者在影像学和功能结果方面具有可比性。

结论

本研究证实了对于隐匿性感染的HSN进行单阶段手术的相关性以及在肱骨干骨固定翻修期间进行系统细菌学采样的价值。

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