Jayachandran C, Singh M K, Singh S D, Banerjee N C
1. Department of Pharmacology, Bihar Veterinary College, Patna, India.
Vet Res Commun. 1987;11(4):353-8. doi: 10.1007/BF00346193.
The study elucidated the pharmacokinetics of streptomycin in healthy lactating she-buffaloes after a single intramuscular (IM) injection (10 mg/kg). The drug attained its peak concentrations of 24.39 +/- 2.67, 0.45 +/- 0.05 and 5.06 +/- 0.18 micrograms/ml at 1, 4 and 1 hour in plasma, milk and uterine fluid respectively. Calculations based on the assumption of a 2-compartment model gave a plasma t1/2 (beta) of 4.01 +/- 0.44 h and an apparent volume of distribution [Vd(area)] of 0.47 +/- 0.06 1/kg. The drug was detectable in the plasma, milk and uterine fluid for 30, 8 and 12 hours, respectively. A therapeutic concentration of the drug was maintained for 6 to 7 hours in the plasma and for around 1 hour only in the uterine fluid. However, a therapeutic level could not be achieved in milk at any time. The results suggest that the drug can be used clinically by the IM route against streptomycin susceptible systemic infections but not those in the uterus and mammary gland.
本研究阐明了链霉素在健康泌乳母水牛单次肌内注射（10毫克/千克）后的药代动力学。药物在血浆、乳汁和子宫液中分别于1小时、4小时和1小时达到峰值浓度，分别为24.39±2.67、0.45±0.05和5.06±0.18微克/毫升。基于二室模型假设的计算得出血浆t1/2（β）为4.01±0.44小时，表观分布容积[Vd(area)]为0.47±0.06升/千克。药物在血浆、乳汁和子宫液中的可检测时间分别为30小时、8小时和12小时。药物在血浆中维持治疗浓度6至7小时，在子宫液中仅维持约1小时。然而，在乳汁中任何时候都无法达到治疗水平。结果表明，该药物可通过肌内注射途径临床用于治疗对链霉素敏感的全身性感染，但不能用于子宫和乳腺感染。
