Department of Pharmacology, Institute of Pharmacy and Pharmacology, School of Pharmaceutical Sciences, Hengyang Medical School.
Department of Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, China.
Anticancer Drugs. 2023 Oct 1;34(9):995-1001. doi: 10.1097/CAD.0000000000001490. Epub 2023 Dec 23.
Serine/threonine protein kinase 25 (STK25) is a critical regulator of ectopic lipid storage, glucose and insulin homeostasis, fibrosis, and meta-inflammation. More and more studies have revealed a strong correlation between STK25 and human diseases. On the one hand, STK25 can affect glucose and fatty acid metabolism in normal cells or tumors. On the other hand, STK25 participates in autophagy, cell polarity, cell apoptosis, and cell migration by activating various signaling pathways. This article reviews the composition and function of STK25, the energy metabolism and potential drugs that may target STK25, and the research progress of STK25 in the occurrence and development of tumors, to provide a reference for the clinical treatment of tumors.
丝氨酸/苏氨酸蛋白激酶 25（STK25）是异位脂质储存、葡萄糖和胰岛素稳态、纤维化和代谢炎症的关键调节因子。越来越多的研究揭示了 STK25 与人类疾病之间的强烈相关性。一方面，STK25 可以影响正常细胞或肿瘤中的葡萄糖和脂肪酸代谢。另一方面，STK25 通过激活各种信号通路参与自噬、细胞极性、细胞凋亡和细胞迁移。本文综述了 STK25 的组成和功能、可能针对 STK25 的能量代谢和潜在药物以及 STK25 在肿瘤发生和发展中的研究进展，为肿瘤的临床治疗提供参考。
