Department of Ophthalmology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, South Korea.
Retina. 2023 May 1;43(5):747-754. doi: 10.1097/IAE.0000000000003703.
To investigate the quantitative characteristics of anastomoses of macular neovascularization (MNV) in neovascular age-related macular degeneration using optical coherence tomography angiography according to the frequency of intravitreal injections.
Eighty-six eyes of 86 patients treated for neovascular age-related macular degeneration were classified into two groups based on the number of intravitreal injections administered over 12 months: stable (<3) and unstable (≥3). Anastomotic areas were defined as areas surrounded by neighboring vessels in the MNV; their total number, mean area, maximal and minimal diameters (i.e., maximal and minimum Feret diameters), and ratio (Feret aspect ratio) were analyzed in the inner and outer areas of the MNV.
Forty-four and 42 eyes were classified into the stable and unstable groups, respectively. The eyes in the unstable group had larger anastomotic areas with longer minimum Feret diameters and longer perimeters in the outer MNV. In the logistic regression analysis, instability was associated with a larger anastomotic area and a longer minimum Feret diameter in the outer MNV. Multivariate analysis revealed that a longer minimum Feret diameter in the outer MNV was the most significant factor ( P = 0.03).
The quantitative characteristics of the anastomotic areas in the MNV might indicate the need for intravitreal injections in patients with neovascular age-related macular degeneration.
通过频度的玻璃体内注射利用光相干断层扫描血管造影术研究新生血管性年龄相关性黄斑变性中黄斑新生血管（MNV）吻合的定量特征。
根据 12 个月内玻璃体内注射次数将 86 例 86 只眼接受新生血管性年龄相关性黄斑变性治疗的患者分为两组：稳定组（＜3 次）和不稳定组（≥3 次）。吻合区被定义为 MNV 中相邻血管包围的区域；分析 MNV 内、外区吻合区的总数、平均面积、最大和最小直径（即最大和最小 Feret 直径）以及比值（Feret 纵横比）。
44 只眼和 42 只眼分别被分为稳定组和不稳定组。不稳定组的眼睛在外 MNV 中具有更大的吻合面积、更长的最小 Feret 直径和更长的周长。在逻辑回归分析中，不稳定与外 MNV 中更大的吻合面积和更长的最小 Feret 直径相关。多变量分析显示，外 MNV 中最小 Feret 直径较长是最显著的因素（P=0.03）。
MNV 吻合区的定量特征可能表明新生血管性年龄相关性黄斑变性患者需要玻璃体内注射。
