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胸壁扩张器乳房重建术中的椎旁阻滞:阿片类药物消耗和患者结局的倾向匹配分析。

Paravertebral Blocks in Tissue Expander Breast Reconstruction: Propensity-Matched Analysis of Opioid Consumption and Patient Outcomes.

机构信息

From the Plastic and Reconstructive Surgery Service.

Breast Surgery Service.

出版信息

Plast Reconstr Surg. 2023 Apr 1;151(4):542e-551e. doi: 10.1097/PRS.0000000000009981. Epub 2022 Dec 5.

Abstract

BACKGROUND

The paravertebral block (PVB) is an adjunctive perioperative pain control method for patients undergoing breast reconstruction that may improve perioperative pain control and reduce narcotic use. This study determined the efficacy of preoperative PVBs for perioperative pain management in patients undergoing tissue expander breast reconstruction.

METHODS

A retrospective review was performed of patients who underwent tissue expander breast reconstruction from December of 2017 to September of 2019. Two patients with PVBs were matched using propensity scoring to one no-block patient. Perioperative analgesic use, pain severity scores on days 2 to 10 after discharge, and BREAST-Q Physical Well-Being scores before surgery and at 2 weeks, 6 weeks, and 3 months after surgery were compared between the two groups.

RESULTS

The propensity-matched cohort consisted of 471 patients (314 PVB and 157 no block). The PVB group used significantly fewer morphine milligram equivalents than the no-block group (53.7 versus 69.8; P < 0.001). Average daily postoperative pain severity scores were comparable, with a maximum difference of 0.3 points on a 0-point to 4-point scale. BREAST-Q Physical Well-Being scores were significantly higher for the PVB group than the no-block group at 6 weeks after surgery (60.6 versus 51.0; P = 0.015) but did not differ significantly at 2 weeks or 3 months after surgery.

CONCLUSIONS

PVBs may help reduce perioperative opioid requirements but did not reduce pain scores after discharge when used as part of an expander-based reconstruction perioperative pain management protocol. Continued research should examine additional or alternative regional block procedures as well as financial cost and potential long-term impact of PVBs.

CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.

摘要

背景

椎旁阻滞(PVB)是一种辅助围手术期疼痛控制的方法,可用于接受乳房重建的患者,以改善围手术期疼痛控制并减少阿片类药物的使用。本研究旨在确定术前 PVB 在接受组织扩张器乳房重建的患者围手术期疼痛管理中的疗效。

方法

回顾性分析了 2017 年 12 月至 2019 年 9 月期间接受组织扩张器乳房重建的患者。采用倾向评分法将接受 PVB 的 2 例患者与未接受 PVB 的 1 例患者进行匹配。比较两组患者围手术期镇痛药使用情况、出院后 2 至 10 天的疼痛严重程度评分以及术前和术后 2 周、6 周和 3 个月的 BREAST-Q 生理健康评分。

结果

倾向性匹配队列包括 471 例患者(PVB 组 314 例,无阻滞组 157 例)。PVB 组患者吗啡毫克当量用量明显少于无阻滞组(53.7 比 69.8;P<0.001)。两组患者平均每日术后疼痛严重程度评分相似,最高差值为 0 分至 4 分评分量表上的 0.3 分。与无阻滞组相比,PVB 组患者在术后 6 周的 BREAST-Q 生理健康评分显著更高(60.6 比 51.0;P=0.015),但在术后 2 周和 3 个月时差异无统计学意义。

结论

PVB 可有助于减少围手术期阿片类药物需求,但在作为基于扩张器的重建围手术期疼痛管理方案的一部分使用时,并未降低出院后的疼痛评分。应继续研究其他或替代的区域阻滞程序以及 PVB 的经济成本和潜在长期影响。

临床问题/证据水平:治疗性,III 级。

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