University of Campinas, Campinas.
Duke University, Durham, NC.
J Glaucoma. 2023 Jun 1;32(6):526-532. doi: 10.1097/IJG.0000000000002156. Epub 2022 Dec 1.
In a cross-sectional study from a Brazilian multiracial population, minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness measurements from OCT showed comparable diagnostic performance in discriminating early to moderate glaucoma from healthy eyes.
The purpose of this study is to compare the ability of MRW and peripapillary retinal nerve fiber layer thickness (RNFLT) measurements in discriminating early to moderate glaucoma from healthy eyes in a Brazilian population.
A total of 155 healthy controls and 118 patients with mild to moderate glaucoma (mean deviation >-12 dB) underwent MRW and RNFLT measurements with optical coherence tomography. Only 1 eye per patient was included in the analysis. A receiver operating characteristic (ROC) regression model was used to evaluate the diagnostic accuracy of MRW and RNFLT, whereas adjusting for age and Bruch membrane opening area. Sensitivities at fixed specificities of 95% were calculated for each parameter.
Global RNFLT and MRW showed comparable area under the ROC curves [0.93 (0.91-0.96) and 0.93 (0.89-0.96), respectively; P =0.973]. Both parameters had similar sensitivities (75% vs. 74%, respectively; P =0.852) at a fixed specificity of 95%. The best sector for diagnosing glaucoma for both parameters was the temporal inferior sector, which showed an area under the ROC curve of 0.93 (0.87-0.96) for RNFLT and 0.91 (0.86-0.95) for MRW ( P =0.320). The temporal inferior sector showed similar sensitivities for RNFLT and MRW measurements (83% vs. 77%, respectively) at a fixed specificity of 95% (P =0.230).
MRW and RNFLT measurements showed comparable diagnostic performance in discriminating early to moderate glaucoma from healthy eyes in a Brazilian multiracial population.
在一项来自巴西多民族人群的横断面研究中，OCT 测量的最小边缘宽度 (MRW) 和视盘周围视网膜神经纤维层厚度在鉴别早期至中度青光眼与健康眼方面具有相当的诊断性能。
本研究旨在比较巴西人群中，MRW 和视盘周围视网膜神经纤维层厚度 (RNFLT) 测量值在鉴别早期至中度青光眼与健康眼方面的能力。
共纳入 155 名健康对照者和 118 名轻度至中度青光眼（平均偏差>-12 dB）患者，进行 MRW 和 RNFLT 测量，采用光学相干断层扫描。每位患者仅纳入 1 只眼进行分析。使用接收者操作特征（ROC）回归模型评估 MRW 和 RNFLT 的诊断准确性，同时调整年龄和 Bruch 膜开口面积。计算每个参数在固定特异度为 95%时的灵敏度。
全视网膜神经纤维层厚度和 MRW 的 ROC 曲线下面积相当[0.93（0.91-0.96）和 0.93（0.89-0.96）；P=0.973]。两个参数在固定特异度为 95%时具有相似的灵敏度（分别为 75%和 74%；P=0.852）。对于两个参数，诊断青光眼的最佳扇区均为颞下扇区，RNFLT 的 ROC 曲线下面积为 0.93（0.87-0.96），MRW 为 0.91（0.86-0.95）（P=0.320）。在固定特异度为 95%时，颞下扇区的 RNFLT 和 MRW 测量值具有相似的灵敏度（分别为 83%和 77%）（P=0.230）。
在巴西多民族人群中，MRW 和 RNFLT 测量值在鉴别早期至中度青光眼与健康眼方面具有相当的诊断性能。
