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[营养对磷和氟化合物诱变活性的修饰作用]

[Modifying effect of nutrition on the mutagenic activity of phosphorus and fluorine compounds].

作者信息

Tazhibaev Sh S, Kozhakhmetova E B, Aldabergenova K U, Mamyrbaev A A

出版信息

Vopr Pitan. 1987 Jul-Aug(4):63-6.

PMID:3673018
Abstract

The test animals were fed with low-grade food during 2-5 months under conditions of acute and chronic action of hydrogen phosphide and hydrogen fluoride induced by inhalation, that resulted in the pronounced impairment of the chromosomal apparatus of the bone marrow cells in the rats. A principal possibility has been established of modification of the hydrogen phosphide and hydrogen fluoride cytogenetic effect by the alimentary action. In particular, it has been found that the effect is significantly higher when the rats are fed with a low-grade ration than under conditions of balanced nutrition.

摘要

在吸入磷化氢和氟化氢的急性和慢性作用条件下,对实验动物连续2至5个月投喂劣质食物,这导致大鼠骨髓细胞的染色体装置出现明显损伤。已经确定通过饮食作用改变磷化氢和氟化氢细胞遗传学效应的主要可能性。特别是,已发现当给大鼠投喂劣质日粮时,其效应明显高于营养均衡的情况。

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