Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, P. R. China.
PLoS One. 2023 Feb 2;18(2):e0281203. doi: 10.1371/journal.pone.0281203. eCollection 2023.
Serum lactate dehydrogenase levels reflect disease status in a variety of organs, but its role in indicating pulmonary function is not yet clear. Therefore, this study explored the correlation between pulmonary function and serum lactate dehydrogenase, and investigated thresholds for changes in pulmonary function indicators in the total population as well as in different strata of the population.
Based on data from the National Health and Nutrition Examination Survey (NHANES) 2011-2012 (n = 3453), univariate and stratified analyses were performed to investigate factors associated with pulmonary function, and multiple regression analysis was used to further investigate the specific relationship with serum lactate dehydrogenase. Smoothed curve fitting, threshold effect and saturation effect analysis were used to explore the threshold level of serum lactate dehydrogenase at the onset of changes in pulmonary function indicators.
Adjusted smoothed curve fit plots showed a linear relationship between serum lactate dehydrogenase levels and forced vital capacity and forced expiratory volume in one second: for each 1 U/L increase in serum lactate dehydrogenase levels, forced vital capacity decreased by 1.24 mL (95% CI = -2.05, -0.42, P = 0.0030) and forced expiratory volume in one second by 1.11 mL (95% CI = -1.82, -0.39, P = 0.0025).
Serum lactate dehydrogenase was negatively and linearly correlated with pulmonary function indices in the total population analyzed. Based on the total population and different population stratifications, this study determined the threshold values of serum lactate dehydrogenase at the onset of decline of pulmonary function in different populations. This provides a new serological monitoring indicator for patients suffering from respiratory diseases and has implications for patients with possible clinical impairment of pulmonary function. However, our cross-sectional study was not able to determine a causal relationship between these two factors, and further research is needed.
血清乳酸脱氢酶水平反映了多种器官的疾病状态，但它在指示肺功能方面的作用尚不清楚。因此，本研究探讨了肺功能与血清乳酸脱氢酶之间的相关性，并研究了总人群以及不同人群肺功能指标变化的阈值。
基于 2011-2012 年全国健康与营养调查（NHANES）的数据（n=3453），进行了单变量和分层分析，以调查与肺功能相关的因素，并使用多元回归分析进一步研究与血清乳酸脱氢酶的具体关系。使用平滑曲线拟合、阈值效应和饱和效应分析来探讨肺功能指标变化开始时血清乳酸脱氢酶的阈值水平。
调整后的平滑曲线拟合图显示血清乳酸脱氢酶水平与用力肺活量和 1 秒用力呼气量之间呈线性关系：血清乳酸脱氢酶水平每增加 1U/L，用力肺活量降低 1.24mL（95%CI=-2.05，-0.42，P=0.0030），1 秒用力呼气量降低 1.11mL（95%CI=-1.82，-0.39，P=0.0025）。
在分析的总人群中，血清乳酸脱氢酶与肺功能指标呈负线性相关。基于总人群和不同人群分层，本研究确定了不同人群肺功能下降开始时血清乳酸脱氢酶的阈值值。这为患有呼吸系统疾病的患者提供了一种新的血清监测指标，并对可能存在肺功能临床损害的患者具有重要意义。然而，我们的横断面研究未能确定这两个因素之间的因果关系，需要进一步研究。
