Penkov N, Sirakova V, Kaponov Kh
Vutr Boles. 1987;26(4):30-5.
The length of the time intervals of the early diastole was studied by the method of Alvares and Goodwin in 30 patients with unstable angina pectoris by means of simultaneous recordings of M-type echocardiogram, ACG,PCG and ECG before and after medicamentous treatment (beta blockers, nitrites with prolonged action, calcium antagonists). The control group was of 33 healthy men. The isovolumetric relaxation period was greatly prolonged in the patients and the active aspiration period was shortened (p less than 0.001). At the end of hospital treatment the interrelations between these two periods changed--the isovolumetric relaxation period shortened (p less than 0.001) and the active aspiration period lengthened (p less than 0.01) without change of the total period of fast relaxation. The slow relaxation period during the time of fast filling and the total fast filling period before and after treatment did not differ from those of the control group. The changes of the time intervals are probably related to the diminished compliance due to myocardial ischemia. The dynamic changes in the course of medicamentous treatment of unstable angina pectoris reflect the lowered restriction of left ventricular filling.
采用阿尔瓦雷斯和古德温的方法，对30例不稳定型心绞痛患者在药物治疗（β受体阻滞剂、长效硝酸盐、钙拮抗剂）前后，通过同步记录M型超声心动图、心音图、心尖搏动图和心电图，研究舒张早期时间间隔的长度。对照组为33名健康男性。患者的等容舒张期显著延长，主动抽吸期缩短（p<0.001）。在住院治疗结束时，这两个时期之间的相互关系发生了变化——等容舒张期缩短（p<0.001），主动抽吸期延长（p<0.01），而快速舒张期的总时长没有改变。快速充盈期的缓慢舒张期以及治疗前后的总快速充盈期与对照组无差异。时间间隔的变化可能与心肌缺血导致的顺应性降低有关。不稳定型心绞痛药物治疗过程中的动态变化反映了左心室充盈受限程度的降低。
