Nakano Yuyako, Takeuchi Jun, Horiguchi Etsuyo, Ota Hikaru, Taki Yosuke, Ito Yasuki, Terasaki Hiroko, Nishiguchi Koji M, Kataoka Keiko
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Ophthalmology, Fujita Health University School of Medicine, Toyoake, Japan; and Department of Ophthalmology, Kyorin University Graduate School of Medicine, Tokyo, Japan.
Retina. 2023 Mar 1;43(3):412-419. doi: 10.1097/IAE.0000000000003676.
To examine the morphologic changes in macular neovascularization (MNV) secondary to age-related macular degeneration after 2 years of aflibercept treatment under a treat-and-extend (T&E) regimen.
This retrospective study analyzed the medical records for 26 eyes of 25 patients diagnosed with treatment-naive neovascular age-related macular degeneration and treated with aflibercept under a treat-and-extend regimen for 2 years. The areas of the MNV and vascular structures were assessed using swept-source optical coherence tomography angiography at baseline and after 2 years of treatment.
The mean MNV area increased significantly from 0.65 ± 0.42 mm 2 at baseline to 0.78 ± 0.45 mm 2 at 2 years. At 2 years, the mean change in the MNV area from baseline was 22% (interquartile range: 4%-60%). The baseline MNV area was negatively correlated with the change ratio of the MNV areas at 2 years and baseline ( R = -0.68, P < 0.001). Nine of the 26 eyes (34.6%) showed newly formed mature vessels, and 7 eyes (26.9%) showed prominently developing preexisting mature vessels.
Macular neovascularization expanded and showed vascular maturation under aflibercept treatment with a treat-and-extend regimen. The smaller the MNV at baseline, the greater is its expansion in 2 years.
在治疗并延长（T&E）方案下，研究阿柏西普治疗2年后年龄相关性黄斑变性继发黄斑新生血管（MNV）的形态学变化。
这项回顾性研究分析了25例初治新生血管性年龄相关性黄斑变性患者的26只眼睛的病历，这些患者在治疗并延长方案下接受阿柏西普治疗2年。在基线期和治疗2年后，使用扫频源光学相干断层扫描血管造影术评估MNV和血管结构的面积。
MNV平均面积从基线时的0.65±0.42mm²显著增加到2年时的0.78±0.45mm²。在2年时，MNV面积相对于基线的平均变化为22%（四分位间距：4%-60%）。基线MNV面积与2年时和基线时MNV面积的变化率呈负相关（R=-0.68，P<0.001）。26只眼中有9只（34.6%）出现新形成的成熟血管，7只眼（26.9%）显示原有成熟血管显著发展。
在治疗并延长方案的阿柏西普治疗下，黄斑新生血管扩张并显示出血管成熟。基线时MNV越小，其在2年内的扩张越大。
