Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, Florida.
Shock. 2023 Feb 1;59(2):145-154. doi: 10.1097/SHK.0000000000002042. Epub 2022 Nov 3.
Burn injury is a significant source of morbidity and mortality in the pediatric population. Although 40,000 pediatric patients in the United States are admitted to the hospital with burn wounds annually, significant differences exist in the management and treatment of these patients, even among highly specialized burn centers. Some aspects of pediatric burn research, such as metabolic changes and nutritional support after burn injury, have been studied extensively; however, in many aspects of burn care, pediatric research lags behind the study of adult populations. This review compares and contrasts a wide array of physiologic and immune responses between children and adults after burn injury. Such a review elucidates where robust research has been conducted, where adult research is applicable to pediatric patients, and where additional pediatric burn research needs to be conducted.
烧伤是儿科人群发病率和死亡率的重要来源。尽管美国每年有 4 万名儿科患者因烧伤伤口住院，但即使在高度专业化的烧伤中心，这些患者的管理和治疗也存在显著差异。一些儿科烧伤研究的方面，如烧伤后代谢变化和营养支持，已经得到了广泛的研究；然而，在烧伤护理的许多方面，儿科研究落后于成人人群的研究。这篇综述比较和对比了烧伤后儿童和成人之间广泛的生理和免疫反应。这样的综述阐明了已经进行了哪些强有力的研究，成人研究适用于儿科患者的哪些方面，以及还需要进行哪些额外的儿科烧伤研究。
