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[各种有机氯农药对大白鼠免疫反应性的影响]

[The effect of various organochlorine pesticides on the immunologic reactivity of the white rat].

作者信息

Giurgea R, Wittenberger C, Frecus G, Manciulea S, Borsa M, Coprean D, Ilyes S

出版信息

Arch Exp Veterinarmed. 1978;32(5):769-74.

PMID:367308
Abstract

Wistar rats, aged 30 and 90 days, received Aldrin and Lindan treatment (8 ppm or 11 ppm) over 60 days, followed by inoculation of E. coli. The capacity of antibody formation was changed but not inhibited. Functional disorders occurred in the thymus (decline of nucleic acids), adrenal gland (decline of Vitamin C), and in the protein synthesis. The toxicity of even smaller Aldrin doses obviously was stronger than that of Lindan. The toxicity of either substance to younger animals was stronger than to individuals in more advanced age.

摘要

30日龄和90日龄的Wistar大鼠接受了为期60天的艾氏剂和林丹处理(8 ppm或11 ppm),随后接种大肠杆菌。抗体形成能力发生了变化但未受到抑制。胸腺(核酸减少)、肾上腺(维生素C减少)以及蛋白质合成出现了功能紊乱。即使是更小剂量的艾氏剂的毒性明显强于林丹。两种物质对年幼动物的毒性均强于对老龄个体的毒性。

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Arch Exp Veterinarmed. 1978;32(5):769-74.
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引用本文的文献

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Role of brain regional GABA: aldrin-induced stimulation of locomotor activity in rat.脑区γ-氨基丁酸的作用:艾氏剂诱导大鼠运动活性增加
Neurochem Res. 2001 Apr;26(4):439-51. doi: 10.1023/a:1010915518292.