大鼠和人体内二甲基苯丙胺的代谢

The metabolism of dimethylamphetamine in rat and man.

Inoue T, Suzuki S

National Research Institute of Police Science, Tokyo, Japan.

Xenobiotica. 1987 Aug;17(8):965-71. doi: 10.3109/00498258709044195.

Abstract

Urinary metabolites of dimethylamphetamine after oral administration to rat and healthy human volunteers have been studied. 2. Six metabolites and unchanged drug were detected in rat urine and the same metabolites except p-hydroxyamphetamine were found in human urine. The major metabolite was dimethylamphetamine N-oxide in both cases, and methamphetamine and amphetamine were also excreted as minor metabolites. 3. Metabolites excreted in three days after administration of the drug to rat amounted to about 57% of the dose and those after administration to man, 53-56%.

摘要

已对大鼠和健康人类志愿者口服二甲基苯丙胺后的尿液代谢物进行了研究。2. 在大鼠尿液中检测到六种代谢物和未变化的药物，在人类尿液中发现了除对羟基苯丙胺外的相同代谢物。在两种情况下，主要代谢物均为二甲基苯丙胺N-氧化物，甲基苯丙胺和苯丙胺也作为次要代谢物排出。3. 给大鼠给药后三天内排出的代谢物约占剂量的57%，给人给药后排出的代谢物占53 - 56%。