School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China; Department of Nephrology, Huzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Huzhou, China.
School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
J Ren Nutr. 2023 May;33(3):397-404. doi: 10.1053/j.jrn.2023.01.005. Epub 2023 Jan 31.
This study aims to provide pooled estimates for the incidence of acute kidney injury (AKI) in overweight, obese, and normal body mass index (BMI) patients, and to assess impact of BMI on mortality and chronic kidney disease (CKD) rates. We conducted literature search using online databases to analyze outcomes of BMI. This meta-analysis included 22 studies. Compared to normal BMI, underweight, overweight, or obese patients had higher risk of having AKI. Underweight individuals had 17% lower CKD risk (relative risk [RR]: 0.83, 95% confidence interval [CI]: 0.75, 0.90) while patients that were overweight (RR: 1.15, 95% CI: 1.08, 1.22) and obese (RR: 1.21, 95% CI: 1.10, 1.33) had higher risk of having CKD. Lower than normal BMI was associated with higher mortality risk (RR: 1.58, 95% CI: 1.35, 1.85), while being overweight or obese correlated with the decreased risk of mortality. An increased risk of AKI combined with an increased risk of mortality calls for renal protective strategies in subjects who are underweight at the time of hospital admission.
本研究旨在提供超重、肥胖和正常体重指数（BMI）患者急性肾损伤（AKI）发病率的汇总估计，并评估 BMI 对死亡率和慢性肾脏病（CKD）发生率的影响。我们使用在线数据库进行文献检索，以分析 BMI 的结果。这项荟萃分析包括 22 项研究。与正常 BMI 相比，体重不足、超重或肥胖患者发生 AKI 的风险更高。体重不足的个体发生 CKD 的风险降低 17%（相对风险 [RR]：0.83，95%置信区间 [CI]：0.75，0.90），而超重（RR：1.15，95% CI：1.08，1.22）和肥胖（RR：1.21，95% CI：1.10，1.33）患者发生 CKD 的风险更高。低于正常 BMI 与更高的死亡率风险相关（RR：1.58，95% CI：1.35，1.85），而超重或肥胖与死亡率降低相关。AKI 风险增加加上死亡率风险增加，呼吁在住院时体重不足的患者中采取肾脏保护策略。
