School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau (SAR), China.
School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, China; State Key Laboratory of Grassland Agroecosystems, Lanzhou University, Lanzhou, China.
Alkaloids Chem Biol. 2023;89:1-37. doi: 10.1016/bs.alkal.2022.06.001. Epub 2022 Aug 2.
Quinolizidine alkaloids isolated from various marine and terrestrial animals and plants are primarily composed of lupinine-, matrine-, and sparteine-type alkaloids. Matrine, phenanthroquinolizidines, bis-quinolizidines, and small molecules from amphibian skins are representative compounds of such alkaloids. Quinolizidine alkaloids harbor anticancer, antibacterial, antiinflammatory, antifibrosis, antiviral, and anti-arrhythmia. In this chapter, we comprehensively outline the biological activity and pharmacological action of quinolizidine alkaloids and discuss new avenues toward the discovery of novel and more efficient drugs based on these naturally occurring compounds. It is urgent for basic research and clinical practice to conduct more targeted comprehensive research based on the lead drugs of quinolizidine alkaloids with significant pharmacological activity.
从各种海洋和陆地动植物中分离得到的喹诺里西啶生物碱主要由羽扇豆碱型、苦参碱型和斯皮诺辛型生物碱组成。苦参碱、菲咯嗪喹诺里西啶、双喹诺里西啶以及来自两栖动物皮肤的小分子是此类生物碱的代表性化合物。喹诺里西啶生物碱具有抗癌、抗菌、抗炎、抗纤维化、抗病毒和抗心律失常等作用。在本章中，我们全面概述了喹诺里西啶生物碱的生物活性和药理作用，并讨论了基于这些天然存在的化合物发现新型和更有效的药物的新途径。基础研究和临床实践迫切需要基于具有显著药理活性的喹诺里西啶生物碱先导药物进行更有针对性的综合研究。
