Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Department of Neurology, The First People's Hospital of XianYang, XianYang, Sha'anxi, China.
BMC Neurol. 2023 Feb 2;23(1):56. doi: 10.1186/s12883-023-03098-6.
This study aimed to assess the clinical characteristics of cerebral venous sinus thrombosis (CVT) patients with new-onset headache and to identify the risk factors for headache in this population.
We retrospectively reviewed the demographic and clinical data of 69 CVT patients recruited between September 2017 and September 2019. Patients were classified into two groups, the headache group and the non-headache group, according to the presence or absence of new-onset headache symptoms at admission. The following characteristics and parameters were measured and analyzed, including gender, age, amount of thromboembolic cerebral venous sinus(ATCVS), and other relevant indicators.
The incidence of headache was 75% in this cohort. The proportion of female patients in the headache group was higher than that in the non-headache group. Patients in the headache group were younger than those without headache. CVT patients of headache group showed higher lymphocyte ratio (LR), blood urea nitrogen (BUN), and intracranial pressure (ICP) compared to the non-headache group, whereas mean corpuscular volume (MCV) and levels of protein (cerebrospinal fluid, CSF) and lactic dehydrogenase (LDH) in CSF were lower in headache patients. The data also revealed younger age and the increased level of chloride ion CI-(CSF) were the risk factors for the occurrence of headache in CVT patients.
Age, LR, MCV, BUN levels, ICP, protein (CSF), and LDH (CSF) in patients with headache were significantly different from those in the non-headache group at admission. Younger age and a level of CI- (CSF) were risk factors for headache in CVT patients. These findings may provide guidance for clinical diagnosis and treatment of CVT.
本研究旨在评估新发头痛的脑静脉窦血栓形成（CVT）患者的临床特征，并确定该人群头痛的危险因素。
我们回顾性分析了 2017 年 9 月至 2019 年 9 月期间招募的 69 例 CVT 患者的人口统计学和临床数据。根据入院时是否出现新发头痛症状，将患者分为头痛组和非头痛组。测量和分析了以下特征和参数，包括性别、年龄、血栓性脑静脉窦（ATCVS）的数量以及其他相关指标。
本队列中头痛的发生率为 75%。头痛组女性患者的比例高于非头痛组。头痛组患者的年龄小于无头痛组。与非头痛组相比，头痛组的 CVT 患者淋巴细胞比值（LR）、血尿素氮（BUN）和颅内压（ICP）较高，而平均红细胞体积（MCV）和蛋白（脑脊液，CSF）和乳酸脱氢酶（LDH）水平较低。数据还显示，年龄较小和氯离子（CSF）水平升高是 CVT 患者头痛发生的危险因素。
头痛患者入院时的年龄、LR、MCV、BUN 水平、ICP、蛋白（CSF）和 LDH（CSF）与非头痛组有显著差异。年龄较小和氯离子（CSF）水平是 CVT 患者头痛的危险因素。这些发现可能为 CVT 的临床诊断和治疗提供指导。
