Taicang Affiliated Hospital of Soochow University, The First People's Hospital of Taicang, 58 Changsheng Road, Suzhou, 215413, China.
Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou, 215123, Jiangsu, China.
Eur J Med Res. 2023 Feb 2;28(1):56. doi: 10.1186/s40001-023-01024-7.
Several randomized clinical trials showed that aspirin could decrease the incidence of preeclampsia (PE) in women at high risk, but data from sources other than traditional clinical trials that investigating the preventive effect of aspirin 75 mg on PE is still lacking, especially in mainland China. We aimed to use Chinese real-world data to estimate the preventive effect of low-dose aspirin (LDA) on PE.
Clinical data of pregnant women who were at high risk of PE and had their first prenatal visit at the affiliated Taicang People's Hospital of Soochow University during November 31, 2018 and May 10, 2021 was retrospectively analyzed. Among the 266 included pregnant women, 115 individuals treated with aspirin 75 mg per day and the other 151 without such treatment were considered as the LDA group and the control group, respectively.
In the LDA group, 64 (55.65%) of 115 pregnant women took aspirin before 16 weeks of gestation. Besides, 12 (10.43%) and 34 (22.52%) women developed PE in the LDA group and control group, respectively; the aspirin prophylaxis was associated with a lower risk of PE (odds ratio = 0.40, 95% confidence interval = 0.20-0.82, P = 0.0098). In addition, LDA is slightly more effective when initiated before 16 weeks of gestation or in those without chronic hypertension, when compared with their counterparts.
Prophylaxis with 75 mg per day of aspirin in high-risk women resulted in a significantly lower incidence of PE than that in the control group.
几项随机临床试验表明，阿司匹林可降低高危孕妇子痫前期（PE）的发生率，但除传统临床试验外，其他来源研究阿司匹林 75mg 对 PE 的预防作用的数据仍然缺乏，尤其是在中国内地。我们旨在使用中国真实世界数据来评估低剂量阿司匹林（LDA）对 PE 的预防作用。
回顾性分析 2018 年 11 月 31 日至 2021 年 5 月 10 日在苏州大学附属太仓人民医院进行首次产前检查的高危孕妇的临床数据。在 266 名纳入的孕妇中，每天服用 75mg 阿司匹林的 115 名孕妇和未服用阿司匹林的 151 名孕妇分别作为 LDA 组和对照组。
在 LDA 组中，115 名孕妇中有 64 名（55.65%）在 16 周前服用了阿司匹林。此外，LDA 组和对照组分别有 12 名（10.43%）和 34 名（22.52%）孕妇发生 PE；阿司匹林预防与 PE 风险降低相关（比值比=0.40，95%置信区间=0.20-0.82，P=0.0098）。此外，与对照组相比，LDA 在 16 周前开始或在无慢性高血压的孕妇中，效果略好。
高危女性每天服用 75mg 阿司匹林可显著降低 PE 的发生率，与对照组相比。
