Kamio Yukinori, Suzuki Takefumi, Nakano Ryo, Musha Hiroaki, Takahashi Kazuma, Ashino Koki, Kanno Hidenori, Kono Michihisa, Nozu Shintaro, Motoi Fuyuhiko
Dept. of Surgery Ⅰ , Yamagata University Graduate School of Medical Science.
Gan To Kagaku Ryoho. 2022 Dec;49(13):1992-1994.
A 78-year-old man with advanced thoracic esophageal cancer underwent radical esophagectomy after neoadjuvant chemotherapy with cisplatin plus 5-FU. He had left adrenal metastasis 10 months after surgery and removed it, but 3 months later he had liver metastases. After 2 courses of chemotherapy with nedaplatin plus 5-FU, resection was performed. One course of nedaplatin plus 5-FU for adjuvant chemotherapy was added, but the patient was followed up without another chemotherapy after surgery because of intestinal obstruction due to infection and increase of the lymphatic cyst in the abdominal cavity. Six months after the liver resection, nodules appeared in the right lung, and 4 months later, multiple nodules extending to both lungs were observed. Therefore, it was judged that there were multiple lung metastases, and administration of nivolumab was started. He has been 3 years since the recurrence of esophageal cancer and 17 months after the start of nivolumab administration, but the recurrence lesion is only progressing to lung metastasis.
一名78岁的晚期胸段食管癌男性患者，在接受顺铂联合5-氟尿嘧啶新辅助化疗后接受了根治性食管切除术。术后10个月出现左肾上腺转移并进行了切除，但3个月后又出现了肝转移。在接受奈达铂联合5-氟尿嘧啶化疗2个疗程后进行了手术切除。术后追加了1个疗程的奈达铂联合5-氟尿嘧啶辅助化疗，但由于感染导致肠梗阻以及腹腔淋巴囊肿增大，患者术后未再进行化疗而是接受随访。肝切除术后6个月，右肺出现结节，4个月后观察到双肺出现多个结节。因此，判断为多发肺转移，开始使用纳武单抗治疗。自食管癌复发以来已过去3年，开始使用纳武单抗治疗后已过去17个月，但复发病灶仅进展为肺转移。
