Sugimoto Tomoki, Inoue Akira, Komori Takamichi, Nishizawa Yujiro, Kagawa Yoshinori, Komatsu Hisateru, Miyazaki Yasuhiro, Tomokuni Akira, Motoori Masaaki, Iwase Kazuhiro, Fujitani Kazumasa
Dept. of Gastroenterological Surgery and Oncology, Osaka General Medical Center.
Gan To Kagaku Ryoho. 2022 Dec;49(13):1603-1605.
In aging society, the number of colorectal cancer patients who take antithrombotic drugs is increasing. However, there are not established guidelines for perioperative management for antithrombotic drugs in laparoscopic surgery. Here, we investigated the clinical outcomes of antithrombotic drugs withdrawal and perioperative heparinization in laparoscopic surgery for colorectal cancer patients taking antithrombotic drugs. From January 2015 to December 2017 in our center, patients who took antithrombotic drugs and underwent laparoscopic surgery for colorectal cancer were reviewed retrospectively. The association between postoperative complications and heparinizations was analyzed. Among 79 patients taking antithrombotic drugs, heparinization was performed in 40 patients(50.6%). The total length of hospital stay in heparinization group was 21 days and significantly longer than 13 days in the non-heparinization group. There were no significant differences in the operation time, intraoperative blood loss, and postoperative complications between the 2 groups. The antithrombotic drugs withdrawal and perioperative heparinization were suggested to be safe and feasible in laparoscopic surgery for patients with colorectal cancer.
在老龄化社会中，服用抗血栓药物的结直肠癌患者数量正在增加。然而，对于腹腔镜手术中抗血栓药物的围手术期管理，尚未建立相关指南。在此，我们调查了服用抗血栓药物的结直肠癌患者在腹腔镜手术中停用抗血栓药物及围手术期肝素化的临床结局。2015年1月至2017年12月期间，对我院中心服用抗血栓药物并接受结直肠癌腹腔镜手术的患者进行回顾性分析。分析术后并发症与肝素化之间的关联。在79例服用抗血栓药物的患者中，40例（50.6%）进行了肝素化。肝素化组的总住院时间为21天，显著长于非肝素化组的13天。两组之间的手术时间、术中出血量和术后并发症无显著差异。对于结直肠癌患者的腹腔镜手术，停用抗血栓药物及围手术期肝素化被认为是安全可行的。
