State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P. R. China.
Department of Endodontology, Kornberg School of Dentistry, Temple University, Philadelphia, PA 19140, United States.
Curr Drug Metab. 2023;24(5):338-352. doi: 10.2174/1389200224666230202155414.
Osteoarthritis (OA) involves lesions of the entire joint and remains one of the health problems plaguing the world. The pathological mechanism of OA is complex and involves multiple signaling pathways. Over 300 million people worldwide are living with OA, which imposes a huge burden on society. Nucleic acid nanomaterials are of interest to the biomedical field due to their small dimension, ideal biocompatibility, and structure editability. Various nucleic acids have been used as therapeutic drugs to regulate the pathogenesis and development of OA. Among them, some can enter the cell by themselves and others with the aid of vectors. Apart from high therapeutic efficiency, nucleic acid nanomaterials also act as carriers for transporting drugs. This paper reviews recent advances in nucleic acid nanomaterials in OA therapy, suggesting that nucleic acid nanomaterials-based therapy has good prospects for development.
骨关节炎（OA）涉及整个关节的病变，仍然是困扰世界的健康问题之一。OA 的病理机制复杂，涉及多个信号通路。全球有超过 3 亿人患有 OA，这给社会带来了巨大的负担。由于其尺寸小、理想的生物相容性和结构可编辑性，核酸纳米材料引起了生物医学领域的关注。各种核酸已被用作治疗药物来调节 OA 的发病机制和发展。其中一些可以自行进入细胞，而另一些则需要载体的帮助。除了高效的治疗效果外，核酸纳米材料还可以作为药物输送载体。本文综述了核酸纳米材料在 OA 治疗中的最新进展，表明基于核酸纳米材料的治疗具有很好的发展前景。
