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在轻至中度抑郁和焦虑症状人群中的适用性及疗效:一项前瞻性随机对照试验方案

The applicability and efficacy of in groups with mild to moderate symptoms of depression and anxiety: A prospective and randomized controlled trial protocol.

作者信息

Zhao Wenqing, Chen Shuangyi, Hu Jun, Zhou Qing, Tao Jing, Gao Rui, Zhang Jie, Su Shanshan, Wang Yuan, Su Yousong, Peng Yihua, Wu Yanru, Fan Qing, Zhang Weibo, Jiang Wenhui, Cai Jun, Qiu Jianyin

机构信息

Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Shanghai Xuhui Mental Health Center, Shanghai, China.

出版信息

Front Psychiatry. 2023 Jan 17;13:991465. doi: 10.3389/fpsyt.2022.991465. eCollection 2022.

DOI:10.3389/fpsyt.2022.991465
PMID:36733416
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9887015/
Abstract

BACKGROUND

Mental health is a global issue requiring global attention. Depression and anxiety are two of the most common mental disorders (CMDs) and are characterized by high incidence and high comorbidity. In recent years, the prolonged COVID-19 pandemic and exacerbated social instability have posed significant challenges to the mental resilience and mental health outcomes of the global population. Now more than ever, with an increase in mental health needs, it has become even more crucial to find an effective solution to provide universal mental healthcare. Psychotherapy is of vital importance for those coping with symptoms of depression and anxiety and is used to enhance mental resilience. However, such therapy can be difficult to access in reality. In this context, the platform will be developed.

OBJECTIVES

As an online self-help platform for psychological intervention, the platform was developed for those who suffer from mild to moderate symptoms of depression and/or anxiety and is tasked with the goal of reducing depressive and anxious symptoms while improving mental resilience. Thus, this study will be carried out to verify its efficacy and applicability.

METHODS

In this parallel-group, randomized controlled trial, a total of 200 mild to moderately depressed and/or anxious adults seeking self-help will be randomly recruited and assigned to either the micro-video psychological intervention group or the wait list control group. Online measurements by self-assessment will be taken at baseline, post-intervention, 1-month, and 3-month follow-up.

RESULTS

The primary results will involve symptoms of depression and anxiety. The secondary results will involve mental resilience. An analysis will be conducted based on the intention-to-treat principle.

DISCUSSION

This trial will examine whether the platform for the relief of symptoms and the enhancement of resilience in a population screened for depression and anxiety symptoms proves effective and applicable. Large-scale resilience enhancement may benefit public mental health in terms of preventive interventions, managing depressive and anxiety symptoms, and promoting mental health. With the -based method being applied, a brief, efficient, and structured intervention model can potentially be established, having the potential to provide necessary and accessible mental support for an extensive target group.

CLINICAL TRIAL REGISTRATION

http://www.chictr.org.cn/, identifier ChiCTR2100043725.

摘要

背景

心理健康是一个需要全球关注的全球性问题。抑郁症和焦虑症是两种最常见的精神障碍(CMDs),其特点是发病率高和共病率高。近年来,长期的新冠疫情和加剧的社会不稳定对全球人口的心理韧性和心理健康状况构成了重大挑战。如今,随着心理健康需求的增加,找到一种有效的解决方案以提供普遍的心理保健变得更加至关重要。心理治疗对于那些应对抑郁和焦虑症状的人至关重要,并且被用于增强心理韧性。然而,在现实中这种治疗可能难以获得。在此背景下,将开发该平台。

目的

作为一个用于心理干预的在线自助平台,该平台是为那些患有轻度至中度抑郁和/或焦虑症状的人开发的,其任务是在提高心理韧性的同时减轻抑郁和焦虑症状。因此,将开展本研究以验证其有效性和适用性。

方法

在这项平行组随机对照试验中,总共将随机招募200名寻求自助的轻度至中度抑郁和/或焦虑的成年人,并将他们分配到微视频心理干预组或等待名单对照组。将在基线、干预后、1个月和3个月随访时通过自我评估进行在线测量。

结果

主要结果将涉及抑郁和焦虑症状。次要结果将涉及心理韧性。将根据意向性分析原则进行分析。

讨论

本试验将检验用于缓解症状和增强韧性的该平台在筛查出抑郁和焦虑症状的人群中是否有效和适用。大规模增强韧性可能在预防性干预、管理抑郁和焦虑症状以及促进心理健康方面有益于公众心理健康。随着基于该平台的方法的应用,有可能建立一个简短、高效且结构化的干预模式,有潜力为广泛的目标群体提供必要且可获得的心理支持。

临床试验注册

http://www.chictr.org.cn/,标识符ChiCTR2100043725 。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33b6/9887015/118ed7b8927d/fpsyt-13-991465-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33b6/9887015/d05754b10767/fpsyt-13-991465-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33b6/9887015/118ed7b8927d/fpsyt-13-991465-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33b6/9887015/d05754b10767/fpsyt-13-991465-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33b6/9887015/118ed7b8927d/fpsyt-13-991465-g002.jpg

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