DEPDC5基因rs1012068和rs5998152多态性与肝细胞癌风险的相关性：一项系统评价和荟萃分析

Correlation of DEPDC5 rs1012068 and rs5998152 Polymorphisms with Risk of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.

作者信息

Zhu Shaoliang, Tang Zhenyong, Zou Mengjie, Tan Tingting, Tang Yi, Chen Yuanyuan, Liang Bin, Xie Dongyi, Yang Yongyu, Xie Shaowei, Xie Guangyuan, Dong Xiaofeng, Liu Tianqi, Tang Yuntian, Yang Jianrong

机构信息

Department of Hepatobiliary, Pancreas and Spleen Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning 530021, China.

Department of Gastrointestinal Endoscopy Center, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning 530021, China.

出版信息

J Oncol. 2023 Jan 24;2023:5957481. doi: 10.1155/2023/5957481. eCollection 2023.

DOI:10.1155/2023/5957481

PMID:36733671

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9889158/

Abstract

BACKGROUND

Emerging evidence has shown that two common genetic polymorphisms within the pleckstrin domain-containing protein 5 (DEPDC5), rs1012068 and rs5998152, may be associated with the risk of hepatocellular carcinoma (HCC), especially in those individuals chronically infected with the hepatitis C virus (HCV) or the hepatitis B virus (HBV). However, these findings have not been consistently replicated in the literature due to limited sample sizes or different etiologies of HCC. Thus, the present systematic review and meta-analysis were performed to resolve this inconsistency.

METHODS

The databases PubMed, Embase, Web of Science, the China National Knowledge Infrastructure, and Scopus were searched up to December 12, 2022. Data from relevant studies were pooled, and odds ratios and 95% confidence intervals were calculated.

RESULTS

A total of 11 case-control studies encompassing 2,609 cases and 8,171 controls on rs1012068 and three encompassing 411 cases and 1,448 controls on rs5998152 were included. Results indicated that the DEPDC5 rs1012068 polymorphism did not significantly increase HCC risk in the total population (allelic model (OR = 1.32, 95% CI = 1.04-1.67, = 0.02); the recessive model (OR = 1.42, 95% CI = 0.96-2.10, = 0.08); the dominant model (OR = 1.43, 95% CI = 1.09-1.87, = 0.01); the homozygous model (OR = 1.61, 95% CI = 1.01-2.57, = 0.05); the heterozygous model (OR = 1.39, 95% CI = 1.09-1.79, = 0.009)). Subgroup analyses based on ethnicity and etiology revealed that the rs1012068 polymorphism, under all five genetic models, was associated with increased HCC risk in Asians or in individuals with chronic HBV infection but not in individuals with chronic HCV infection. A significant association was also observed between rs5998152 and HCV-related HCC risk in Asians chronically infected with HCV under allelic, dominant, and heterozygous models.

CONCLUSION

Our study suggests that the DEPDC5 rs1012068 polymorphism increases HCC risk, especially in Asians with chronic HBV infection, while the rs5998152 polymorphism increases HCC risk in Asians with chronic HCV infection.

摘要

背景

新出现的证据表明，含普列克底物蛋白结构域蛋白5（DEPDC5）内的两个常见基因多态性，即rs1012068和rs5998152，可能与肝细胞癌（HCC）风险相关，尤其是在那些慢性感染丙型肝炎病毒（HCV）或乙型肝炎病毒（HBV）的个体中。然而，由于样本量有限或HCC病因不同，这些发现尚未在文献中得到一致的重复验证。因此，进行了本系统评价和荟萃分析以解决这一不一致性问题。

方法

检索了截至2022年12月12日的PubMed、Embase、Web of Science、中国知网和Scopus数据库。汇总相关研究的数据，并计算比值比和95%置信区间。

结果

共纳入11项病例对照研究，涉及rs1012068的2609例病例和8171例对照，以及3项涉及rs5998152的411例病例和1448例对照。结果表明，DEPDC5 rs1012068多态性在总体人群中并未显著增加HCC风险（等位基因模型（OR = 1.32，95%CI = 1.04 - 1.67，P = 0.02）；隐性模型（OR = 1.42，95%CI = 0.96 - 2.10，P = 0.08）；显性模型（OR = 1.43，95%CI = 1.09 - 1.87，P = 0.01）；纯合子模型（OR = 1.61，95%CI = 1.01 - 2.57，P = 0.05）；杂合子模型（OR = 1.39，95%CI = 1.09 - 1.79，P = 0.009））。基于种族和病因的亚组分析显示，在所有五种遗传模型下，rs1012068多态性与亚洲人或慢性HBV感染个体的HCC风险增加相关，但与慢性HCV感染个体无关。在等位基因、显性和杂合子模型下，还观察到rs5998152与慢性HCV感染的亚洲人的HCV相关HCC风险之间存在显著关联。