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Modelling optically pumped magnetometer interference in MEG as a spatially homogeneous magnetic field.将光学泵磁强计干扰模型化为 MEG 中的空间均匀磁场。
Neuroimage. 2021 Dec 1;244:118484. doi: 10.1016/j.neuroimage.2021.118484. Epub 2021 Aug 19.
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4
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用于移动脑磁图测量的自旋交换光泵浦核自旋自补偿系统。

Spin exchange optically pumped nuclear spin self compensation system for moving magnetoencephalography measurement.

作者信息

Chen Yao, Zhao Libo, Ma Yintao, Yu Mingzhi, Wang Yanbin, Zhang Ning, Wei Kai, Jiang Zhuangde

机构信息

State Key Laboratory for Manufacturing Systems Engineering, International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies,Overseas Expertise Introduction Center for Micro/Nano Manufacturing and Nano Measurement Technologies Discipline Innovation, School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an 710049, China.

Xi'an Jiaotong University Suzhou Institute, Suzhou 215123, China.

出版信息

Biomed Opt Express. 2022 Oct 18;13(11):5937-5951. doi: 10.1364/BOE.474862. eCollection 2022 Nov 1.

DOI:10.1364/BOE.474862
PMID:36733752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9872881/
Abstract

Recording moving magnetoencephalograms (MEGs ), in which a person's head can move freely as the brain's magnetic field is recorded, has been a key subject in recent years. Here, we describe a method based on an optically pumped atomic co-magnetometer (OPACM) for recording moving MEGs. In the OPACM, hyper-polarized nuclear spins produce a magnetic field that blocks the background fluctuation low-frequency magnetic field noise while the rapidly changing MEG signal is recorded. In this study, the magnetic field compensation was studied theoretically, and we found that the compensation is closely related to several parameters such as the electron spin magnetic field, nuclear spin magnetic field, and holding magnetic field. Furthermore, the magnetic field compensation was optimized based on a theoretical model . We also experimentally studied the magnetic field compensation and measured the responses of the OPACM to different magnetic field frequencies. We show that the OPACM clearly suppresses low-frequency (under 1 Hz) magnetic fields. However, the OPACM responses to magnetic field frequencies around the band of the MEG. A magnetic field sensitivity of 3 fT/Hz was achieved. Finally, we performed a simulation of the OPACM during utilization for moving MEG recording. For comparison, the traditional compensation system for moving MEG recording is based on a coil that is around 2 m in dimension , while our compensation system is only 2 mm in dimension .

摘要

记录移动脑磁图(MEG)是近年来的一个关键课题,在记录过程中,当大脑磁场被记录时,人的头部可以自由移动。在此,我们描述一种基于光泵原子共磁强计(OPACM)的记录移动MEG的方法。在OPACM中,超极化核自旋产生一个磁场,该磁场在记录快速变化的MEG信号时阻挡背景波动低频磁场噪声。在本研究中,对磁场补偿进行了理论研究,我们发现补偿与电子自旋磁场、核自旋磁场和保持磁场等几个参数密切相关。此外,基于理论模型对磁场补偿进行了优化。我们还通过实验研究了磁场补偿,并测量了OPACM对不同磁场频率的响应。我们表明,OPACM能明显抑制低频(低于1 Hz)磁场。然而,OPACM对MEG频段附近的磁场频率有响应。实现了3 fT/Hz的磁场灵敏度。最后,我们对用于移动MEG记录的OPACM进行了模拟。相比之下,传统的用于移动MEG记录的补偿系统基于一个尺寸约为2米的线圈,而我们的补偿系统尺寸仅为2毫米。