[Effect of a series of vasoactive drugs on the compensatory adaptive processes of the brain during acute experimental cerebral venous stasis].

In 120 rats with acute intracranial venous congestion the authors investigated the influence of some vasoactive drugs on compensatory-adaptive processes in the brain. They studied reactions of the nerve cells, pericellular and perivascular edema, and vessels to the administration of cavinton, trental, xanthinol nicotinate, troxevasin, and euphyllin. It has been demonstrated that vasoactive drugs have a varying influence on the compensatory processes in the brain. Thus, cavinton and trental significantly improve the venous outflow from the cranial cavity, sharply reduce cerebral edema, and stimulate reparative processes. Xanthinol nicotinate deteriorates compensatory-adaptive reactions, troxevasin exerts a favourable effect at an early stage, euphyllin acts in a biphasic mode.