Department of Hematology and Oncology, Kovai Medical Center and Hospital, Coimbatore, India.
Kovai Medical Center and Hospital, Coimbatore, India.
J Oncol Pharm Pract. 2023 Jul;29(5):1271-1274. doi: 10.1177/10781552231152414. Epub 2023 Feb 3.
Blepharoptosis, commonly referred to as ptosis or eyelid sagging, is a condition where the upper eyelid droops over the eye. It can be congenital or acquired and is caused by the weakening of the eyelid muscles.
We present a case of a 3-year-old boy with T-cell acute lymphoblastic leukemia who developed bilateral ptosis while on treatment with Berlin-Frankfurt Munster-98 protocol.
MANAGEMENT & OUTCOME: The patient was diagnosed with bilateral ptosis due to vincristine, the primary agent in the induction phase of the protocol. The addition of the neuroregenerative agents and supportive measures led to marked improvement, followed by complete resolution within 3 weeks.
Vincristine is an anticancer agent with known neurotoxicity, which has a significant role in treating hematological malignancies and sarcoma. In many studies, the addition of neuroregenerative agents such as pyridoxine and pyridostigmine has been noted to hasten recovery without any documented side effects. Similar findings were also drawn from our research due to India's higher incidence of vincristine-induced neurotoxicity. It is essential to promptly diagnose and manage symptoms at the earliest to prevent the risk of permanent nerve damage and inferior quality of life for the patient.
上睑下垂，通常称为眼睑下垂或眼睑松弛，是指上眼睑下垂覆盖眼睛的一种情况。它可以是先天性的也可以是后天获得的，是由眼睑肌肉的弱化引起的。
我们报告了一例 3 岁男孩患有 T 细胞急性淋巴细胞白血病，在接受柏林-法兰克福-明斯特-98 方案治疗时出现双侧上睑下垂。
患者被诊断为双侧上睑下垂，这是由于方案诱导阶段的主要药物长春新碱引起的。添加神经再生剂和支持性措施后，症状明显改善，3 周内完全缓解。
长春新碱是一种具有已知神经毒性的抗癌药物，在治疗血液系统恶性肿瘤和肉瘤方面具有重要作用。在许多研究中，添加神经再生剂，如吡哆醇和吡啶斯的明，已被证明可以加速恢复，而没有任何记录的副作用。我们的研究也得出了类似的发现，这是由于印度长春新碱诱导的神经毒性发生率较高。及时诊断和治疗症状至关重要，以防止永久性神经损伤和患者生活质量下降的风险。
