Department of Nutrition Sciences, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nutr Cancer. 2023;75(3):948-959. doi: 10.1080/01635581.2023.2173552. Epub 2023 Feb 3.
This study aimed to determine the relationship between food pattern and dietary intake before and during chemotherapy with the severity of gastrointestinal side effects, cancer-related fatigue, and chemotherapy-induced pain. This study was performed on 204 patients with breast cancer who were undergoing chemotherapy. Dietary pattern was collected by food frequency questionnaire and dietary intake during chemotherapy using a 24-hour food recall questionnaire. The severity of chemotherapy side effects including nausea, vomiting, constipation, diarrhea, CRF, and pain was also assessed by valid questionnaires. The relationship between dietary pattern and mean score of chemotherapy side effects was calculated using linear regression analysis. Three dietary patterns were extracted from the participants. After adjusting the effect of all possible confounders, no significant relationship was found between the dietary pattern one year before the start of treatment and the mean of chemotherapy side effects severity. Although the mean of daily energy intake with the severity of nausea and vomiting (r = -0.258, P-value <0.01), constipation, fatigue, and pain have a significant inverse relationship. Nutrition education and following a healthy diet are needed to reduce the severity of chemotherapy side effects during this period.
本研究旨在确定化疗前后食物模式与胃肠道副作用严重程度、癌症相关疲劳和化疗引起的疼痛之间的关系。该研究纳入了 204 名正在接受化疗的乳腺癌患者。通过食物频率问卷收集膳食模式，通过 24 小时食物回忆问卷收集化疗期间的膳食摄入量。采用有效问卷评估化疗副作用（恶心、呕吐、便秘、腹泻、CRF 和疼痛）的严重程度。采用线性回归分析计算膳食模式与化疗副作用严重程度的平均得分之间的关系。从参与者中提取了三种膳食模式。调整所有可能的混杂因素的影响后，治疗开始前一年的饮食模式与化疗副作用严重程度的平均值之间没有显著关系。尽管每日能量摄入与恶心和呕吐（r = -0.258，P 值 <0.01）、便秘、疲劳和疼痛严重程度呈显著负相关。在此期间，需要营养教育和遵循健康饮食来减轻化疗副作用的严重程度。
