Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, United States.
Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, United States.
Invest Ophthalmol Vis Sci. 2023 Feb 1;64(2):8. doi: 10.1167/iovs.64.2.8.
The purpose of this study was to define the nature and extent of sensitivity loss using chromatic perimetry in diabetics who have mild or no retinopathy.
Thirty-four individuals with type II diabetes mellitus who have mild nonproliferative diabetic retinopathy (MDR; N = 17) or no diabetic retinopathy (NDR; N = 17) and 15 visually normal, non-diabetic controls participated. Sensitivity was assessed along the horizontal visual field meridian using an Octopus 900 perimeter. Measurements were performed under light- and dark-adapted conditions using long-wavelength (red) and short-wavelength (blue) Goldmann III targets. Cumulative defect curves (CDCs) were constructed to determine whether field sensitivity loss was diffuse or localized.
Sensitivity was reduced significantly under light-adapted conditions for both stimulus colors for the NDR (mean defect ± SEM = -2.1 dB ± 0.6) and MDR (mean defect ± SEM = -4.0 dB ± 0.7) groups. Sensitivity was also reduced under dark-adapted conditions for both stimulus colors for the NDR (mean defect ± SEM = -1.9 dB ± 0.7) and MDR (mean defect ± SEM = -4.5 ± 1.0 dB) groups. For both diabetic groups, field loss tended to be diffuse under light-adapted conditions (up to 6.9 dB loss) and localized under dark-adapted conditions (up to 15.4 dB loss).
Visual field sensitivity losses suggest neural abnormalities in early stage diabetic eye disease and the pattern of the sensitivity losses differed depending on the adaptation conditions. Chromatic perimetry may be useful for subtyping individuals who have mild or no diabetic retinopathy and for better understanding their neural dysfunction.
本研究旨在定义轻度或无视网膜病变的糖尿病患者使用色觉视野检查出现敏感性损失的性质和程度。
34 名 2 型糖尿病患者，其中 17 名患有轻度非增生性糖尿病视网膜病变（MDR），17 名无糖尿病视网膜病变（NDR），15 名视力正常的非糖尿病对照者参与了本研究。使用 Octopus 900 周边视野计，在水平视野子午线测量敏感性。在明适应和暗适应条件下，使用长波长（红色）和短波长（蓝色）Goldmann III 目标进行测量。构建累积缺陷曲线（CDC），以确定视野敏感性损失是弥漫性的还是局限性的。
在明适应条件下，两种刺激颜色的 NDR（平均缺陷±SEM=-2.1dB±0.6）和 MDR（平均缺陷±SEM=-4.0dB±0.7）组的敏感性均显著降低。在暗适应条件下，两种刺激颜色的 NDR（平均缺陷±SEM=-1.9dB±0.7）和 MDR（平均缺陷±SEM=-4.5dB±1.0）组的敏感性也均降低。对于两个糖尿病组，在明适应条件下，视野损失呈弥漫性（最大损失达 6.9dB），而在暗适应条件下呈局限性（最大损失达 15.4dB）。
视野敏感性损失表明早期糖尿病眼病存在神经异常，且敏感性损失的模式取决于适应条件。色觉视野检查可能有助于对轻度或无糖尿病视网膜病变的个体进行亚型分类，并更好地理解他们的神经功能障碍。
