Brusamolino Matteo, Maccarana Agnese, Giambuzzi Ilaria, Muratori Manuela, Bonalumi Giorgia, Calligaris Giuseppe, Agrifoglio Marco, Agostoni Piergiuseppe
Centro Cardiologico Monzino, IRCCS, Milano - Sezione Cardiovascolare, Dipartimento di Scienze Cliniche e di Comunità (DISCCO), Università degli Studi, Milano.
Centro Cardiologico Monzino, IRCCS, Milano.
G Ital Cardiol (Rome). 2023 Feb;24(2):122-124. doi: 10.1714/3963.39419.
We report the case of a 28-year-old Caucasian patient symptomatic for low-threshold angina. Coronary angiography ruled out significant coronary stenosis. He was diagnosed with familial hypercholesterolemia and severe aortic stenosis in a setting of bicuspid valve disease. Preoperative evaluation showed diffuse atheromatous disease and severe calcification of the ascending aorta. The patient was treated by endarterectomy of the ascending aorta, non-coronary sinus enlargement patch and aortic valve replacement. This case report emphasizes the role of aortic valve disease in patients with familial hypercholesterolemia and highlights the complexity of surgical management of this condition.
我们报告了一例28岁有低阈值心绞痛症状的白种人患者。冠状动脉造影排除了严重冠状动脉狭窄。他被诊断为家族性高胆固醇血症，并在二叶式瓣膜病的情况下患有严重主动脉瓣狭窄。术前评估显示升主动脉有弥漫性动脉粥样硬化疾病和严重钙化。该患者接受了升主动脉内膜切除术、非冠状动脉窦扩大补片和主动脉瓣置换术治疗。本病例报告强调了主动脉瓣疾病在家族性高胆固醇血症患者中的作用，并突出了这种疾病手术治疗的复杂性。
