Gavic Emily A, Achen Sarah E, Fox Phillip R, Benjamin Eduardo J, Goodwin Jonathan, Gunasekaran Tamilselvam, Schober Karsten E, Tjostheim Sonja S, Vickers John, Ward Jessica L, Russell Duncan S, Rishniw Mark, Hamer Sarah A, Saunders Ashley B
1BluePearl Veterinary Partners, Southfield, MI.
2The Animal Medical Center, New York, NY.
J Am Vet Med Assoc. 2023 Feb 2;261(5):705-712. doi: 10.2460/javma.22.10.0445. Print 2023 May 1.
To describe the clinical presentation and outcome in dogs diagnosed with Trypanosoma cruzi infection in nonendemic areas and to survey veterinary cardiologists in North America for Chagas disease awareness.
12 client-owned dogs; 83 respondents from a veterinary cardiology listserv.
A retrospective, multicenter medical records review to identify dogs diagnosed with American trypanosomiasis between December 2010 and December 2020. An anonymous online survey was conducted August 9 to 22, 2022.
Diagnosis was made using indirect fluorescent antibody titer (n = 9), quantitative PCR assay (1), or postmortem histopathology (2). Time spent in Texas was < 1 year (n = 7) or 2 to 8 years (5). Time in nonendemic areas prior to diagnosis was < 1 year (n = 10) and > 3 years (2). Eleven had cardiac abnormalities. Of the 12 dogs, 5 had died unexpectedly (range, 1 to 108 days after diagnosis), 4 were still alive at last follow-up (range, 60 to 369 days after diagnosis), 2 were euthanized because of heart disease (1 and 98 days after diagnosis), and 1 was lost to follow-up. Survey results were obtained from 83 cardiologists in North America, of which the self-reported knowledge about Chagas disease was limited in 49% (41/83) and 69% (57/83) expressed interest in learning resources.
Results highlight the potential for encountering dogs with T cruzi infection in nonendemic areas and need for raising awareness about Chagas disease in North America.
描述在非流行地区被诊断为感染克氏锥虫的犬的临床表现及预后，并调查北美兽医心脏病专家对恰加斯病的认知情况。
12只客户拥有的犬；来自兽医心脏病学邮件列表的83名受访者。
进行一项回顾性、多中心病历审查，以确定2010年12月至2020年12月期间被诊断为美洲锥虫病的犬。于2022年8月9日至22日进行了一项匿名在线调查。
诊断采用间接荧光抗体滴度（n = 9）、定量PCR检测（1）或死后组织病理学检查（2）。在得克萨斯州停留的时间<1年（n = 7）或2至8年（5）。诊断前在非流行地区的时间<1年（n = 10）且>3年（2）。11只犬有心脏异常。12只犬中，5只意外死亡（诊断后1至108天），4只在最后一次随访时仍存活（诊断后60至369天），2只因心脏病实施安乐死（诊断后1天和98天），1只失访。调查结果来自北美83名心脏病专家，其中49%（41/83）自我报告对恰加斯病的了解有限，69%（57/83）表示对学习资源感兴趣。
结果凸显了在非流行地区遇到感染克氏锥虫犬的可能性，以及在北美提高对恰加斯病认识的必要性。
