National Joint Local Engineering Laboratory for Cell Engineering and Biomedicine Technique, Guizhou Province Key Laboratory of Regenerative Medicine, Key Laboratory of Adult Stem Cell Translational Research (Chinese Academy of Medical Sciences).
Department of Clinical Medical College.
Am J Clin Oncol. 2023 Mar 1;46(3):121-128. doi: 10.1097/COC.0000000000000979. Epub 2023 Feb 3.
Signaling pathways play significant roles in the occurrence, development, and treatment of pancreatic cancer (PC). The main treatment options are surgery, chemotherapy, radiotherapy, arterial infusion chemotherapy in interventional therapy, and immunotherapy. Many studies have shown that signaling pathways perform a function in the occurrence and development of PC, for instance, phosphoinositide 3-kinase (PI3K)/AKT, nuclear factor-κB, Ras, interleukin (IL)-17B/IL-17RB, Wnt, and hepatocyte growth factor/c-MET, which play roles in the proliferation, metastasis, invasion, inhibition of apoptosis, promotion of angiogenesis, and drug resistance of PC. Interaction of signaling pathways has an impact on the biological behavior of PC; for example, activation of the neurotensin/NTSR1 pathway, which can activate mitogen-activated protein kinase, nuclear factor-κB, and other pathways related to PC stem cells, play an important role in PC, and an increase in their number is associated with the Wnt/β-catenin and PI3K pathways. Chemotherapy is the main method for the treatment of PC, but drug resistance limits its use. In addition, abnormal activation of IL-17B/IL-17RB signaling pathway is associated with drug resistance. This article discusses the signaling pathways that play different roles in the occurrence and development of PC, as well as current research on signaling pathways in PC treatment.
信号通路在胰腺癌（PC）的发生、发展和治疗中起着重要作用。主要的治疗选择是手术、化疗、放疗、介入治疗中的动脉灌注化疗和免疫治疗。许多研究表明，信号通路在 PC 的发生和发展中起作用，例如磷酸肌醇 3-激酶（PI3K）/AKT、核因子-κB、Ras、白细胞介素（IL）-17B/IL-17RB、Wnt 和肝细胞生长因子/c-MET，它们在 PC 的增殖、转移、侵袭、抑制凋亡、促进血管生成和耐药性方面发挥作用。信号通路的相互作用对 PC 的生物学行为有影响；例如，神经降压素/NTSR1 通路的激活可以激活丝裂原活化蛋白激酶、核因子-κB 等与 PC 干细胞相关的通路，在 PC 中起着重要作用，其数量的增加与 Wnt/β-catenin 和 PI3K 通路有关。化疗是治疗 PC 的主要方法，但耐药性限制了其应用。此外，IL-17B/IL-17RB 信号通路的异常激活与耐药性有关。本文讨论了在 PC 的发生和发展中起不同作用的信号通路，以及目前关于 PC 治疗中信号通路的研究。
