State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510006, China.
The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Poult Sci. 2023 Apr;102(4):102501. doi: 10.1016/j.psj.2023.102501. Epub 2023 Jan 14.
Since 1999, QX-like (GI-19) avian infectious bronchitis viruses have been the predominant strains in China till now. Vaccination is the most effective way to control the disease, while live attenuated vaccine is widely used. In the current research, we evaluated the effect of several monovalent and bivalent live IBV vaccines in young chickens against the QX-like (GI-19) IBV infection. The results showed that monovalent 4/91 and bivalent Ma5+LDT3 vaccines could provide efficient protection in day-old chickens that reduced morbidity and mortality, ameliorated histopathology lesions, and reduced viral loads were observed. These data suggest that vaccination through nasal route with monovalent 4/91 or bivalent Ma5+LDT3 in day-old chickens could serve a safe and effective vaccination strategy for controlling QX-like (GI-19) infectious bronchitis virus.
自 1999 年以来，QX 样（GI-19）禽传染性支气管炎病毒一直是中国的主要流行株。疫苗接种是控制该病最有效的方法，而活疫苗广泛应用。在目前的研究中，我们评估了几种单价和双价活 IBV 疫苗对 QX 样（GI-19）IBV 感染的幼鸡的效果。结果表明，单价 4/91 和双价 Ma5+LDT3 疫苗能为 1 日龄雏鸡提供高效保护，降低发病率和死亡率，减轻组织病理学损伤，降低病毒载量。这些数据表明，通过滴鼻途径接种单价 4/91 或双价 Ma5+LDT3 疫苗可为控制 QX 样（GI-19）传染性支气管炎病毒提供一种安全有效的免疫策略。
