Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Graduated, School of Applied Sciences, University of Brighton, Brighton, UK.
Pathol Res Pract. 2023 Mar;243:154348. doi: 10.1016/j.prp.2023.154348. Epub 2023 Jan 30.
Long non-coding RNAs (lncRNAs) have more than 200 nucleotides and do not encode proteins. At the same time, they can regulate various biological functions and therefore play an essential role as oncogenes or tumor suppressors in human cancers. MAFG-AS1 is an antisense RNA of MAF BZIP Transcription Factor G (MAFG) located at chromosome 17q25.3 head-to-head with the MAFG encoding gene containing a transcript size of 1895 bp. Accumulating evidence shows that MAFG-AS1 is overexpressed in many cancers, functions as an oncogene, and is significantly associated with poor clinical characteristics and prognosis. In this review, we first discuss the recent literature regarding the role of MAFG-AS1 in different cancers as well as its diagnostic and prognostic values. Then we will provide insights into its biological functions, such as its role in cancer progression, competing endogenous RNA (ceRNA) activity, regulation of EMT, glycolysis, energy metabolism, transcription factors, proteasomal degradation, and signaling pathways.
长链非编码 RNA（lncRNA）长度超过 200 个核苷酸，不编码蛋白质。同时，它们可以调节各种生物功能，因此在人类癌症中作为癌基因或肿瘤抑制因子发挥着重要作用。MAFG-AS1 是位于 17q25.3 染色体上的 MAF BZIP 转录因子 G（MAFG）的反义 RNA，与 MAFG 编码基因头对头，转录大小为 1895 bp。越来越多的证据表明，MAFG-AS1 在许多癌症中过度表达，作为癌基因发挥作用，与不良的临床特征和预后显著相关。在这篇综述中，我们首先讨论了关于 MAFG-AS1 在不同癌症中的作用及其诊断和预后价值的最新文献。然后，我们将深入探讨其生物学功能，如其在癌症进展、竞争性内源 RNA（ceRNA）活性、EMT 调控、糖酵解、能量代谢、转录因子、蛋白酶体降解和信号通路中的作用。
