非编码 RNA 对家畜肌内脂肪细胞调控的研究进展。

Research progress of non-coding RNAs regulation on intramuscular adipocytes in domestic animals.

机构信息

Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.

出版信息

Gene. 2023 Apr 15;860:147226. doi: 10.1016/j.gene.2023.147226. Epub 2023 Feb 2.

DOI:10.1016/j.gene.2023.147226

PMID:36736503

Abstract

Intramuscular fat (IMF) is the main determinant of the economic value of domestic animal meat, and has a vital impact on the sensory quality characteristics, while the content of IMF is mainly determined by the size and number of intramuscular adipocytes. In recent years, due to the development of sequencing technology and omics technology, a large number of non-coding RNAs have been identified in intramuscular adipocytes. Non-coding RNAs are a kind of RNA regulatory factors with biological functions but without translation function, which mainly include microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs). These non-coding RNAs regulate the key genes of intramuscular adipocyte growth and development at post-transcriptional level through a variety of regulatory mechanisms, and affect the number and size of intramuscular adipocytes, thus affecting the content of IMF. Here, the review summarizes the candidate non-coding RNAs (miRNAs, lncRNAs, circRNAs) and genes involved in the regulation of intramuscular adipocytes, the related regulation mechanism and signaling pathways, in order to provide reference for further clarifying the molecular regulation mechanism of non-coding RNAs on intramuscular adipocytes in domestic animals.

摘要

肌内脂肪（IMF）是家畜肉经济价值的主要决定因素，对感官质量特性有重要影响，而 IMF 的含量主要取决于肌内脂肪细胞的大小和数量。近年来，由于测序技术和组学技术的发展，在肌内脂肪细胞中已经鉴定出大量的非编码 RNA。非编码 RNA 是一类具有生物功能但没有翻译功能的 RNA 调控因子，主要包括 microRNAs（miRNAs）、长链非编码 RNA（lncRNAs）和环状 RNA（circRNAs）。这些非编码 RNA 通过多种调控机制在转录后水平上调节肌内脂肪细胞生长和发育的关键基因，影响肌内脂肪细胞的数量和大小，从而影响 IMF 的含量。本文综述了参与调节肌内脂肪细胞的候选非编码 RNA（miRNAs、lncRNAs、circRNAs）及其相关基因、相关调控机制和信号通路，以期为进一步阐明非编码 RNA 对家畜肌内脂肪细胞的分子调控机制提供参考。