Deviaterikova Alena, Kasatkin Vladimir, Malykh Sergey
Neurocognitive Laboratory, Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, 117997, Russia.
Research Institute for Brain Development and Peak Performance, Peoples' Friendship University of Russia, Moscow, 117198, Russia.
Cerebellum. 2024 Feb;23(1):197-203. doi: 10.1007/s12311-023-01525-5. Epub 2023 Feb 4.
The cerebellum is involved in motor and non-motor functions. Cerebellar lesions can underlie the disruption of various executive functions. The violation of executive functions in cerebellar lesions is a serious problem, since children, after completing treatment, must return to school, finish their education, and get a profession. One of the important executive functions is working memory, which contributes to academic success. Deficits of verbal working memory in cerebellar tumors have been studied, in contrast to visual-spatial working memory. To assess this issue, 101 patients who survived cerebellar tumors and 100 healthy control subjects performed a visual-spatial working memory test. As a result, in children who survived cerebellar tumors, visual-spatial working memory is impaired compared to the control group. Moreover, with age, and hence the time since the end of treatment, the number of elements that children can retain in visual-spatial working memory increases, but still remains smaller compared to the control group. Our findings complement the idea of cerebellar involvement in visual-spatial working memory and suggest that it is disrupted by cerebellar lesions in children.
小脑参与运动和非运动功能。小脑病变可能是各种执行功能障碍的基础。小脑病变时执行功能的受损是一个严重问题，因为儿童在完成治疗后必须重返学校、完成学业并获得职业技能。重要的执行功能之一是工作记忆，它有助于学业成功。与视觉空间工作记忆相比，小脑肿瘤患者的言语工作记忆缺陷已得到研究。为评估这一问题，101名小脑肿瘤存活患者和100名健康对照者进行了视觉空间工作记忆测试。结果发现，与对照组相比，小脑肿瘤存活儿童的视觉空间工作记忆受损。此外，随着年龄增长，也就是治疗结束后的时间推移，儿童在视觉空间工作记忆中能够保留的元素数量会增加，但与对照组相比仍然较少。我们的研究结果补充了小脑参与视觉空间工作记忆的观点，并表明儿童小脑病变会破坏视觉空间工作记忆。
