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反应性神经生物学调节作为纤维肌痛的精准医学治疗方法

REAC Neurobiological Modulation as a Precision Medicine Treatment for Fibromyalgia.

作者信息

Silva Analízia, Barcessat Ana Rita, Gonçalves Rebeca, Landre Cleuton, Brandão Lethícia, Nunes Lucas, Feitosa Hyan, Costa Leonardo, Silva Raquel, de Lima Emanuel, Monteiro Ester Suane, Rinaldi Arianna, Fontani Vania, Rinaldi Salvatore

机构信息

Department of Biological and Health Sciences, Federal University of Amapá-UNIFAP, Macapá 68903-419, Brazil.

Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.

出版信息

J Pers Med. 2023 May 27;13(6):902. doi: 10.3390/jpm13060902.

DOI:10.3390/jpm13060902
PMID:37373891
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10304207/
Abstract

Fibromyalgia syndrome (FS) is a disorder characterized by widespread musculoskeletal pain and psychopathological symptoms, often associated with central pain modulation failure and dysfunctional adaptive responses to environmental stress. The Radio Electric Asymmetric Conveyer (REAC) technology is a neuromodulation technology. The aim of this study was to evaluate the effects of some REAC treatments on psychomotor responses and quality of life in 37 patients with FS. Tests were conducted before and after a single session of Neuro Postural Optimization and after a cycle of 18 sessions of Neuro Psycho Physical Optimization (NPPO), using evaluation of the functional dysmetria (FD) phenomenon, Sitting and Standing (SS), Time Up and Go (TUG) tests for motor evaluation, Fibromyalgia Impact Questionnaire (FIQ) for quality of life. The data were statistically analyzed, and the results showed a statistically significant improvement in motor response and quality of life parameters, including pain, as well as reduced FD measures in all participants. The study concludes that the neurobiological balance established by the REAC therapeutic protocols NPO and NPPO improved the dysfunctional adaptive state caused by environmental and exposomal stress in FS patients, leading to an improvement in psychomotor responses and quality of life. The findings suggest that REAC treatments could be an effective approach for FS patients, reducing the excessive use of analgesic drugs and improving daily activities.

摘要

纤维肌痛综合征(FS)是一种以广泛的肌肉骨骼疼痛和精神病理症状为特征的疾病,常与中枢性疼痛调节功能障碍以及对环境应激的适应性反应功能失调有关。无线电波不对称传输器(REAC)技术是一种神经调节技术。本研究的目的是评估某些REAC治疗对37例FS患者心理运动反应和生活质量的影响。在单次神经姿势优化治疗前后以及18次神经心理生理优化(NPPO)治疗周期后进行测试,采用功能性辨距不良(FD)现象评估、坐立(SS)测试、起立行走(TUG)测试进行运动评估,使用纤维肌痛影响问卷(FIQ)评估生活质量。对数据进行统计学分析,结果显示所有参与者的运动反应和生活质量参数(包括疼痛)有统计学意义的改善,FD测量值降低。研究得出结论,REAC治疗方案NPO和NPPO建立的神经生物学平衡改善了FS患者因环境和暴露应激引起的适应性功能障碍状态,导致心理运动反应和生活质量得到改善。研究结果表明,REAC治疗可能是FS患者的一种有效方法,可减少镇痛药的过度使用并改善日常活动。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db34/10304207/2845da18b841/jpm-13-00902-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db34/10304207/a01dcd7b35fe/jpm-13-00902-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db34/10304207/2845da18b841/jpm-13-00902-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db34/10304207/a01dcd7b35fe/jpm-13-00902-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db34/10304207/2845da18b841/jpm-13-00902-g002.jpg

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Biomedicines. 2023 Apr 7;11(4):1119. doi: 10.3390/biomedicines11041119.
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Central Sensitization in Spondyloarthritis: The Crossroads between Disease Activity, Health-related Quality of Life and Fibromyalgia.脊柱关节炎中的中枢敏化:疾病活动度、健康相关生活质量和纤维肌痛的交汇点。
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