使用动态计算机模型估算经皮氧分压的决定因素。

Estimation of the determinants of transcutaneous oxygen tension using a dynamic computer model.

作者信息

Talbot-Pedersen A, Neuman M R, Saidel G M, Jacobsen E

机构信息

Case Western Reserve University, Cleveland, Ohio.

出版信息

Adv Exp Med Biol. 1987;220:269-73. doi: 10.1007/978-1-4613-1927-6_49.

DOI:10.1007/978-1-4613-1927-6_49

PMID:3673772

Abstract

A dynamic model for oxygen transport within the outer layers of the skin and a tcPO2 sensor has been developed. By comparing model simulations with clinical measurements from adults, it is possible to analyze some of the physiologic and physical determinants of the tcPO2 measurement. The results indicate that the permeability of the epidermis is a significant parameter when using a microcathode sensor. Using this model, the values obtained for normalized stratum papillare blood flow and metabolic oxygen consumption of the dermis are higher than those seen for other models.

摘要

已经开发出一种用于皮肤外层内氧气传输的动态模型以及一个经皮氧分压（tcPO2）传感器。通过将模型模拟结果与成人的临床测量值进行比较，就有可能分析tcPO2测量的一些生理和物理决定因素。结果表明，使用微阴极传感器时，表皮的渗透性是一个重要参数。利用该模型，获得的真皮乳头层归一化血流值和代谢耗氧量高于其他模型中的值。