2017 年日本大血管血管炎的全国临床和流行病学研究。

Nationwide clinical and epidemiological study of large-vessel vasculitis in Japan in 2017.

机构信息

Division of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Tokyo 162-8666, Japan.

Department of Public Health and Epidemiology, Meiji Pharmaceutical University, Kiyose, Tokyo 204-8588, Japan.

出版信息

Mod Rheumatol. 2023 Dec 22;34(1):167-174. doi: 10.1093/mr/road019.

DOI:10.1093/mr/road019

PMID:36737863

Abstract

OBJECTIVE

We conducted a nationwide epidemiological study to estimate the number of patients with Takayasu arteritis (TAK) and giant cell arteritis (GCA) in Japan and to describe the clinical characteristics of these patients.

METHODS

The first survey was designed to estimate the number of patients with TAK and GCA who were treated at medical institutions in Japan in 2017. The second survey was designed to collect data on the clinical characteristics of the patients who were reported in the first survey.

RESULTS

Of the 3495 institutions selected for the first survey, 1960 (56.1%) responded. The number of patients with clinically diagnosed TAK and GCA was estimated to be 5320 (95% confidence interval, 4810-5820) and 3200 (95% confidence interval, 2830-3570), respectively. Aortic regurgitation was reported in 35% of patients with TAK, and eye-related comorbidities were observed in 30.4% of patients with GCA. The common carotid and internal carotid arteries were the most frequently involved in patients with TAK (62.7%). Subclavian artery lesions and thoracic or abdominal aorta lesions were reported in 31% and 42.6% of patients with GCA, respectively.

CONCLUSIONS

The number of patients with TAK and GCA was estimated simultaneously, and significant differences in clinical characteristics were observed between the two diseases.

摘要

目的

我们进行了一项全国性的流行病学研究，以估计日本 Takayasu 动脉炎（TAK）和巨细胞动脉炎（GCA）患者的数量，并描述这些患者的临床特征。

方法

第一项调查旨在估计 2017 年在日本医疗机构接受治疗的 TAK 和 GCA 患者人数。第二项调查旨在收集第一项调查中报告的患者的临床特征数据。

结果

在被选为第一项调查的 3495 家机构中，有 1960 家（56.1%）做出了回应。经临床诊断的 TAK 和 GCA 患者数量估计分别为 5320 例（95%置信区间，4810-5820）和 3200 例（95%置信区间，2830-3570）。35%的 TAK 患者出现主动脉瓣反流，30.4%的 GCA 患者出现眼部相关合并症。TAK 患者最常受累的血管是颈总动脉和颈内动脉（62.7%）。GCA 患者分别有 31%和 42.6%出现锁骨下动脉病变和胸或腹主动脉病变。