College of Food Science and Engineering, Henan University of Technology, Zhengzhou 450001, China.
College of Food Science and Engineering, Henan University of Technology, Zhengzhou 450001, China.
Food Res Int. 2023 Feb;164:112400. doi: 10.1016/j.foodres.2022.112400. Epub 2022 Dec 27.
Polysaccharide from Rosa roxburghii Tratt fruit (RTFP) ameliorates high-fat diet (HFD)-induced colitis in mice. However, it is still unknown whether the gut microbiota can mediate the anti-colitis effects of RTFP in mice. This research aims to investigate the role of gut microbes in modulating RTFP in colitis mice through fecal microbiota transplantation (FMT). The findings demonstrated that RTFP exhibited prebiotic effects on HFD-induced colitis mice. After FMT treatment (transplatation of the microbiota from the fecal sample to each recipient daily), the fecal microbiota of RTFP-treated donor mice remarkably alleviated colitis-related symptoms (e.g., colonic inflammation, loss of body weight, gut microbiota dysbiosis, and loss of barrier integrity) and upregulated the expression of tight junction proteins compared to the HFD-treated donor mice. Overall, RTFP can reduce the severity of HFD-induced colitis by regulating gut microbiota.
玫瑰茄果多糖（RTFP）可改善高脂肪饮食（HFD）诱导的小鼠结肠炎。然而，肠道微生物群是否能介导 RTFP 在小鼠中的抗结肠炎作用仍不清楚。本研究旨在通过粪便微生物群移植（FMT）研究肠道微生物群在调节 RTFP 对结肠炎小鼠的作用。研究结果表明，RTFP 对 HFD 诱导的结肠炎小鼠具有益生元作用。经 FMT 处理（每天从粪便样本中移植微生物群到每个受体）后，与 HFD 处理的供体小鼠相比，接受 RTFP 处理的供体小鼠的粪便微生物群显著缓解了结肠炎相关症状（如结肠炎症、体重减轻、肠道微生物群失调和屏障完整性丧失），并上调了紧密连接蛋白的表达。总的来说，RTFP 通过调节肠道微生物群可以减轻 HFD 诱导的结肠炎的严重程度。
