Hori Daijiro, Nomura Yohei, Taniguchi Yosuke, Yuri Koichi, Mieno Makiko, Kimura Naoyuki, Yamaguchi Atsushi
Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
Division of Cardiology, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
J Artif Organs. 2024 Mar;27(1):23-31. doi: 10.1007/s10047-023-01384-1. Epub 2023 Feb 4.
The purpose of this study was to evaluate the effect of decalcification and existence of stent at the aortic annulus on mitral annular motion after surgery.
Patients receiving Inspiris (Edwards, CA, USA, n = 117), Intuity (Edwards, n = 36), Perceval (Corcym, London, UK, n = 36), Evolut (Medtronics, MN, USA, n = 81) and Sapien 3 (Edwards, n = 250) were included in the study. Mitral annular motion was evaluated by E', using tissue doppler imaging.
After surgery, a significant increase in E' was observed in patients receiving Inspiris (Before: 4.2 ± 1.21 cm/s vs. Discharge: 5.0 ± 1.23 cm/s, p < 0.001). Mid-term echocardiogram performed at 11.8 ± 2.2 months after the surgery, showed a significant increase in E' in patients receiving Inspiris (Before: 4.2 ± 1.21 cm/s vs. Mid-term: 5.2 ± 1.20 cm/s, p < 0.001) and Perceval (Before: 3.9 ± 1.34 cm/s vs. Mid-term: 4.5 ± 1.24 cm/s, p = 0.008). Univariable analysis showed a higher increase in E' in patients with decalcified annulus compared to those without decalcified annulus (Decalcification: 0.15 ± 1.321 cm/s vs. No Decalcification: 0.66 ± 1.420 cm/s, p < 0.001). Multivariable analysis showed that balloon-expandable stent (β = - 0.6960, p < 0.001) and self-expanding stent (r = - 0.3592, p = 0.042) were independent limiting factors for an increase in E' at discharge. However, balloon-expandable stent (β = - 0.8382, p < 0.001), and not self-expanding stent (β = - 0.3682, p = 0.089), was a remaining independent factor associated with E' at mid-term follow-up.
Decalcification was associated with improvement in E' after surgery. Balloon-expandable stent was an independent limiting factor for improvement in E' up to 1 year after the surgery, while self-expanding stent was not a significant factor after 1 year.
本研究旨在评估主动脉瓣环脱钙及支架存在对术后二尖瓣环运动的影响。
本研究纳入了接受英派瑞斯(美国加利福尼亚州爱德华兹公司,n = 117)、因图伊特(爱德华兹公司,n = 36)、珀西瓦尔(英国伦敦科尔西姆公司,n = 36)、艾弗洛特(美国明尼苏达州美敦力公司,n = 81)和 Sapien 3(爱德华兹公司,n = 250)的患者。采用组织多普勒成像通过 E' 评估二尖瓣环运动。
术后,接受英派瑞斯的患者 E' 显著增加(术前:4.2±1.21 cm/s vs. 出院时:5.0±1.23 cm/s,p < 0.001)。术后 11.8±2.2 个月进行的中期超声心动图显示,接受英派瑞斯的患者 E' 显著增加(术前:4.2±1.21 cm/s vs. 中期:5.2±1.20 cm/s,p < 0.001),接受珀西瓦尔的患者 E' 也显著增加(术前:3.9±1.34 cm/s vs. 中期:4.5±1.24 cm/s,p = 0.008)。单因素分析显示,与未脱钙瓣环的患者相比,脱钙瓣环患者的 E' 升高幅度更大(脱钙:0.15±1.321 cm/s vs. 未脱钙:0.66±1.420 cm/s,p < 0.001)。多因素分析显示,球囊扩张式支架(β = -0.6960,p < 0.001)和自膨胀式支架(r = -0.3592,p = 0.042)是出院时 E' 升高的独立限制因素。然而,球囊扩张式支架(β = -0.8382,p < 0.001)而非自膨胀式支架(β = -0.3682,p = 0.089)是中期随访时与 E' 相关的剩余独立因素。
脱钙与术后 E' 的改善相关。球囊扩张式支架是术后 1 年内 E' 改善的独立限制因素,而自膨胀式支架在 1 年后不是显著因素。