奥密克戎变异株出现后，罗氏 cobas Liat 检测试验对 SARS-CoV-2 和流感病毒的检测评估。
Evaluation of the cobas Liat detection test for SARS-CoV-2 and influenza viruses following the emergence of the SARS-CoV-2 Omicron variant.
机构信息
Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Department of Laboratory Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea.
Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
出版信息
Diagn Microbiol Infect Dis. 2023 Apr;105(4):115891. doi: 10.1016/j.diagmicrobio.2023.115891. Epub 2023 Jan 4.
OBJECTIVES
This study assessed the clinical performance of the cobas Liat SARS‑CoV‑2 & Influenza A/B assay (LiatCOVID/flu) for the detection of both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses during the SARS-CoV-2 Omicron outbreak.
METHODS
Residual nasopharyngeal swab samples (NPS) previously tested with cobas SARS-CoV-2 & Influenza A/B for SARS-CoV-2 and with the Allplex Respiratory Panel 1 for influenza viruses were collected. All samples were submitted to the LiatCOVID/flu assay.
RESULTS
A total of 1147 samples were collected comprising 167 SARS-CoV-2-positive, 556 SARS-CoV-2-negative, 224 influenza-positive, and 200 influenza-negative cases. The positive percent agreement (PPA)/negative percent agreement (NPA) of LiatCOVID/flu for SARS-CoV-2 and influenza viruses compared to the previously tested methods were 100% of 100% and 99.6% of 100%, respectively.
CONCLUSIONS
The LiatCOVID/flu assay shows an acceptable performance in the detection of SARS-CoV-2 and influenza viruses using NPS samples.
目的
本研究评估 cobas Liat SARS-CoV-2 & Influenza A/B 检测试剂盒（LiatCOVID/flu）在 SARS-CoV-2 奥密克戎变异株流行期间同时检测严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）和流感病毒的临床性能。
方法
收集了先前使用 cobas SARS-CoV-2 & Influenza A/B 检测试剂盒检测 SARS-CoV-2 和 Allplex Respiratory Panel 1 检测流感病毒的鼻咽拭子（NPS）剩余样本。所有样本均提交至 LiatCOVID/flu 检测试剂盒进行检测。
结果
共收集了 1147 份样本，包括 167 份 SARS-CoV-2 阳性、556 份 SARS-CoV-2 阴性、224 份流感阳性和 200 份流感阴性病例。LiatCOVID/flu 检测试剂盒与先前检测方法相比，对 SARS-CoV-2 和流感病毒的阳性符合率（PPA）/阴性符合率（NPA）分别为 100%/100%和 99.6%/100%。
结论
LiatCOVID/flu 检测试剂盒使用 NPS 样本检测 SARS-CoV-2 和流感病毒时，性能可接受。
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