Department of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province 410000, PR China.
Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province 410000, PR China.
Int Immunopharmacol. 2023 Mar;116:109819. doi: 10.1016/j.intimp.2023.109819. Epub 2023 Feb 2.
Carnosic acid (CA) is a polyphenolic diterpene from rosemary extract with anti-tumor and anti-inflammatory activities. Numerous reports have focused on its anti-tumor ability, while the exact mechanisms underlying its anti-inflammation remains unclear. Here, we have identified that CA is a potent inhibitor of NLRP3 inflammasome in vitro and in vivo. CA not only reduces NLRP3 expression by blocking NF-κB activation, but also inhibits NLRP3 inflammasome assembly and activation by suppressing mitochondrial ROS production and interrupting NLRP3-NEK7 interaction. Furthermore, in mouse models, CA alleviates lipopolysaccharide-induced acute systemic inflammation and MSU-induced peritonitis via NLRP3. Taken together, our data demonstrated the inhibitory effect of CA on NLRP3 inflammasome and pointed out the potential application of CA in the treatment of NLRP3-driven diseases.
迷迭香酸（CA）是一种来源于迷迭香提取物的多酚二萜，具有抗肿瘤和抗炎活性。许多研究都集中在其抗肿瘤能力上，而其抗炎的确切机制尚不清楚。在这里，我们已经确定 CA 是体外和体内 NLRP3 炎性小体的有效抑制剂。CA 通过阻断 NF-κB 激活不仅降低 NLRP3 的表达，还通过抑制线粒体 ROS 产生和中断 NLRP3-NEK7 相互作用来抑制 NLRP3 炎性小体的组装和激活。此外，在小鼠模型中，CA 通过 NLRP3 减轻脂多糖诱导的急性全身炎症和 MSU 诱导的腹膜炎。总之，我们的数据表明 CA 对 NLRP3 炎性小体有抑制作用，并指出 CA 在治疗 NLRP3 驱动的疾病方面的潜在应用。
