Department of Pathology, The University of Chicago Medicine, 5841 South Maryland Avenue, MC 6101, Room S-638, Chicago, IL 60637, USA.
Department of Pathology, The University of Chicago Medicine, 5841 South Maryland Avenue, MC 6101, Room S-638, Chicago, IL 60637, USA.
Surg Pathol Clin. 2023 Mar;16(1):131-150. doi: 10.1016/j.path.2022.09.012. Epub 2022 Dec 9.
Neuroendocrine neoplasms (NENs) span virtually all organ systems and exhibit a broad spectrum of behavior, from indolent to highly aggressive. Historically, nomenclature and grading practices have varied widely across, and even within, organ systems. However, certain core features are recapitulated across anatomic sites, including characteristic morphology and the crucial role of proliferative activity in prognostication. A recent emphasis on unifying themes has driven an increasingly standardized approach to NEN classification, as delineated in the World Health Organization's Classification of Tumours series. Here, we review recent developments in NEN classification, with a focus on NENs of the pancreas and lungs.
神经内分泌肿瘤（NENs）几乎涉及所有器官系统，并表现出广泛的行为谱，从惰性到高度侵袭性。历史上，命名法和分级实践在器官系统之间甚至在内部都存在很大差异。然而，某些核心特征在解剖部位之间是重复出现的，包括特征性形态和增殖活性在预后中的关键作用。最近对统一主题的强调推动了对 NEN 分类的越来越标准化的方法，如世界卫生组织的肿瘤分类系列中所阐述的。在这里，我们回顾了 NEN 分类的最新进展，重点关注胰腺和肺部的 NEN。
