Xiong Lifeng, Zhou Liang
Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA.
Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA.
Trends Immunol. 2023 Mar;44(3):150-152. doi: 10.1016/j.it.2023.01.010. Epub 2023 Feb 2.
Distinguishing between commensal and pathogenic bacteria to generate appropriate responses (tolerance vs. immunogenicity) is a key decision that the human immune system must make to maintain homeostasis. Recently, Clasen and colleagues reported a distinct allosteric interaction between bacterial flagellin and host Toll-like receptor 5 (TLR5), which may shed light on these differences.
区分共生菌和病原菌以产生适当反应（耐受与免疫原性）是人类免疫系统为维持体内平衡必须做出的关键决定。最近，克拉森及其同事报道了细菌鞭毛蛋白与宿主 Toll 样受体 5（TLR5）之间一种独特的变构相互作用，这可能有助于阐明这些差异。
