Liu Bao-Peng, Jia Cun-Xian
Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China; Center for Suicide Prevention Research, Shandong University, Jinan, Shandong, China.
Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China; Center for Suicide Prevention Research, Shandong University, Jinan, Shandong, China.
Psychiatry Res. 2023 Mar;321:115076. doi: 10.1016/j.psychres.2023.115076. Epub 2023 Jan 24.
This study aims to explore the joint associations of shift work and sleep patterns with incident depression. The present prospective cohort using data from UK biobank, included 220,651 participants aged 38 to 71 years recruited between 2006 and 2010. Every participant finished a self-completed touch-screen questionnaire. Hazards ratios (HRs) with corresponding 95% confidence intervals (CIs) of incident depression were reported for shift work and sleep patterns by Cox-proportional hazard models. The average follow-up time was 12.13±1.94 years and the incidence rate of depression was 2.95 (2.89-3.02) per 1000 person-years. After fully adjustment, the participants with irregular and permanent night shifts companied by any sleep pattern were significantly associated with increased risk of incident depression compared with no shift work companied by favorable sleep patterns. The females seemed to be more vulnerable when having night shifts and unfavorable sleep patterns compared with the males. The increased risk of incident depression associated with shift work regardless of night shifts and evening/weekend shifts was not able to offset by favorable sleep patterns. The workers with unhealthy sleep patterns, especially inappropriate sleep duration and insomnia companied by shift work schedule should be paid more attention considering higher risk of depression.
本研究旨在探讨轮班工作和睡眠模式与新发抑郁症之间的联合关联。本前瞻性队列研究使用了英国生物银行的数据，纳入了2006年至2010年间招募的220,651名年龄在38至71岁之间的参与者。每位参与者都完成了一份自我填写的触摸屏问卷。通过Cox比例风险模型报告了轮班工作和睡眠模式的新发抑郁症风险比（HR）及其相应的95%置信区间（CI）。平均随访时间为12.13±1.94年，抑郁症发病率为每1000人年2.95（2.89 - 3.02）。经过充分调整后，与没有轮班工作且睡眠模式良好相比，有不规律和长期夜班且伴有任何睡眠模式的参与者新发抑郁症风险显著增加。与男性相比，女性在值夜班且睡眠模式不佳时似乎更易患病。无论白班、夜班还是晚班/周末班，轮班工作所带来的新发抑郁症风险增加都无法通过良好的睡眠模式来抵消。考虑到抑郁症风险较高，对于睡眠模式不健康的工作者，尤其是那些睡眠时间不当且伴有轮班工作安排的失眠者，应给予更多关注。
