Shift work schedule and sleep patterns in relation to incident depression: Evidence from a prospective cohort study.

This study aims to explore the joint associations of shift work and sleep patterns with incident depression. The present prospective cohort using data from UK biobank, included 220,651 participants aged 38 to 71 years recruited between 2006 and 2010. Every participant finished a self-completed touch-screen questionnaire. Hazards ratios (HRs) with corresponding 95% confidence intervals (CIs) of incident depression were reported for shift work and sleep patterns by Cox-proportional hazard models. The average follow-up time was 12.13±1.94 years and the incidence rate of depression was 2.95 (2.89-3.02) per 1000 person-years. After fully adjustment, the participants with irregular and permanent night shifts companied by any sleep pattern were significantly associated with increased risk of incident depression compared with no shift work companied by favorable sleep patterns. The females seemed to be more vulnerable when having night shifts and unfavorable sleep patterns compared with the males. The increased risk of incident depression associated with shift work regardless of night shifts and evening/weekend shifts was not able to offset by favorable sleep patterns. The workers with unhealthy sleep patterns, especially inappropriate sleep duration and insomnia companied by shift work schedule should be paid more attention considering higher risk of depression.